Acyl-CoA dehydrogenase: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=ACAD | |abbr=ACAD | ||
|description='''Acyl-CoA dehydrogenases''' ACADs are localized in the mitochondrial matrix. | |description='''Acyl-CoA dehydrogenases''' ACADs are localized in the mitochondrial matrix. Several ACADs are distinguished: short-chain (SCAD), medium-chain (MCAD), and long-chain (LCAD). ACAD9 is expressed in human brain. ACADs catalyze the reaction | ||
:::: acyl-CoA + FAD → ''trans''-2-enoyl-CoA + FADH<sub>2</sub> | |||
|info=Wanders RJ, Ruiter JP, IJLst L, Waterham HR, Houten SM (2010) The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results. J Inherit Metab Dis 33:479-94. doi: 10.1007/s10545-010-9104-8. PMID: 20490924 | |info=Wanders RJ, Ruiter JP, IJLst L, Waterham HR, Houten SM (2010) The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results. J Inherit Metab Dis 33:479-94. doi: 10.1007/s10545-010-9104-8. PMID: 20490924 | ||
}} | }} |
Latest revision as of 09:08, 17 March 2023
Description
Acyl-CoA dehydrogenases ACADs are localized in the mitochondrial matrix. Several ACADs are distinguished: short-chain (SCAD), medium-chain (MCAD), and long-chain (LCAD). ACAD9 is expressed in human brain. ACADs catalyze the reaction
- acyl-CoA + FAD → trans-2-enoyl-CoA + FADH2
Abbreviation: ACAD
Reference: Wanders RJ, Ruiter JP, IJLst L, Waterham HR, Houten SM (2010) The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results. J Inherit Metab Dis 33:479-94. doi: 10.1007/s10545-010-9104-8. PMID: 20490924
MitoPedia topics: Enzyme