Begum 2023 WIREs Mech Dis
Begum HM, Shen K (2023) Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells. WIREs Mech Dis 15:e1595. https://doi.org/10.1002/wsbm.1595 |
Begum HM, Shen K (2023) WIREs Mech Dis
Abstract: Cancer cells have an abnormally high mitochondrial membrane potential (ΞΞ¨m ), which is associated with enhanced invasive properties in vitro and increased metastases in vivo. The mechanisms underlying the abnormal ΞΞ¨m in cancer cells remain unclear. Research on different cell types has shown that ΞΞ¨m is regulated by various intracellular mechanisms such as by mitochondrial inner and outer membrane ion transporters, cytoskeletal elements, and biochemical signaling pathways. On the other hand, the role of extrinsic, tumor microenvironment (TME) derived cues in regulating ΞΞ¨m is not well defined. In this review, we first summarize the existing literature on intercellular mechanisms of ΞΞ¨m regulation, with a focus on cancer cells. We then offer our perspective on the different ways through which the microenvironmental cues such as hypoxia and mechanical stresses may regulate cancer cell ΞΞ¨m .
β’ Bioblast editor: Gnaiger E
Correction: FADH2 and Complex II
- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
- Gnaiger E (2024) Complex II ambiguities β FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - Β»Bioblast linkΒ«
Labels: Pathology: Cancer
Regulation: mt-Membrane potential