- high-resolution terminology - matching measurements at high-resolution
ETS pathway types
Description
Substrate types in SUIT protocols are types of reduced substrates feeding electrons into the electron transfer system (ETS) at different levels of mitochondrial pathways. Substrates of type 1 may be artificial electron donors essentially bypassing the ETS and feeding electrons directly into the terminal electron acceptor, cytochrome c oxidase (CIV) or alternative oxidases (single enzymatic step). Substrates of type 2 feed electrons into Complex III (CIII) with further electron transfer downstream of the Q-junction. Substrates of type 3 feed electrons into respiratory complexes directly upstream of the Q-junction, whereas substrates of type 4 feed electrons into dehydrogenases and enzyme systems upstream of the type 3 pathway level.
MitoPedia concepts: "MitoFit Quality Control System" is not in the list (MiP concept, Respiratory state, Respiratory control ratio, SUIT concept, SUIT protocol, SUIT A, SUIT B, SUIT C, SUIT state, Recommended, ...) of allowed values for the "MitoPedia concept" property.
MitoFit Quality Control System"MitoFit Quality Control System" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
MitoPedia topics: Substrate and metabolite
- On the pathway level of converging NADH- and FADH2-linked dehydrogenases, including the TCA cycle and beta-oxidation:
- N: NADH-linked substrates (CI-linked)
- F: FADH2-linked substrates (FAO)
- On the pathway level of electron transfer complexes converging at the Q-junction:
- S: Succinate (CII-linked)
- Gp: Glycerophosphate (CGpDH-linked)
- On the single step level of cytochrome c oxidase (CIV), the terminal step in the aerobic electron transfer system:
