Pyruvate carboxylase: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=PC | |abbr=PC | ||
|description='''Pyruvate carboxylase''' synthesizes [[oxaloacetate]] from [[pyruvate]] as an [[anaplerosis |anaplerotic reaction]] in the mitochondrial matrix of the liver and kidney of higher animals, representing an alternative to the [[malic enzyme]] pathway to oxaloacetate. Carboxylation of pyruvate to oxaloacetate requires Mg-ATP. Acetyl CoA is a positive modulator. | |description='''Pyruvate carboxylase''' synthesizes [[oxaloacetate]] from [[pyruvate]] and CO<sub>2</sub> as an [[anaplerosis |anaplerotic reaction]] in the mitochondrial matrix of the liver and kidney of higher animals, representing an alternative to the [[malic enzyme]] pathway to oxaloacetate (which is more important in heart an skeletal muscle) or the [[phosphoenolpyruvate carboxykinase]] reaction (compare glyoxylate cycle in plants and microorganisms). Carboxylation of pyruvate to oxaloacetate requires Mg-ATP. Acetyl CoA is a strong positive modulator. PC can form oxaloacetate from pyruvate to remove an excess of oxaloacetate which inhibits succinate dehydrogenase. | ||
|info=[[Lehninger 1970 Worth Publishers]], [[Gnaiger 2014 MitoPathways]] | |info=[[Lehninger 1970 Worth Publishers]], [[Gnaiger 2014 MitoPathways]] | ||
|type=Enzyme | |type=Enzyme |
Revision as of 15:58, 24 January 2015
Description
Pyruvate carboxylase synthesizes oxaloacetate from pyruvate and CO2 as an anaplerotic reaction in the mitochondrial matrix of the liver and kidney of higher animals, representing an alternative to the malic enzyme pathway to oxaloacetate (which is more important in heart an skeletal muscle) or the phosphoenolpyruvate carboxykinase reaction (compare glyoxylate cycle in plants and microorganisms). Carboxylation of pyruvate to oxaloacetate requires Mg-ATP. Acetyl CoA is a strong positive modulator. PC can form oxaloacetate from pyruvate to remove an excess of oxaloacetate which inhibits succinate dehydrogenase.
Abbreviation: PC
Reference: Lehninger 1970 Worth Publishers, Gnaiger 2014 MitoPathways
MitoPedia topics: Enzyme