Romanello 2016 Abstract Mito Xmas Meeting Innsbruck

Contribution of mitochondrial dynamics to age-related muscle loss.

Link:

Romanello V, Sandri M (2016)

Event: Mito Xmas Meeting 2016 Innsbruck AT

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes, cancer, obesity, renal and cardiac failure and in aging-sarcopenia. In these catabolic conditions the mitochondrial content, morphology and function are greatly affected. A dysfunctional mitochondrial network trigger catabolic signaling pathways which feed-forward to the nucleus to promote the activation of muscle atrophy. Optimised mitochondrial function is strictly maintained by the coordinated activation of different mitochondrial quality control pathways such as mitochondrial fusion and fission. Muscle loss associated with aging-sarcopenia is characterized by alterations in the balance of mitochondrial dynamics. We showed that in humans there is an important age-dependent decrease of mitochondria-shaping proteins that correlate with muscle wasting and weakness that can be counteracted by regular exercise. In agreement, muscle-specific acute deletion of either Opa1 or Drp1 leads to exacerbated muscle loss. Moreover, fusion impairment in muscles reverberates to whole body inducing multi-organ precocious aging and premature death. Given the relevant role of balanced mitochondrial dynamics in muscle atrophy and to dissect the mechanistic insights linking mitochondria to sarcopenia, we investigate here the consequences of simultaneous disruption of both, mitochondrial fission and fusion, and thus freezing mitochondrial dynamics in the adult stage of skeletal muscles. All together, these findings are important for the understanding of the molecular pathways that controls muscle mass. This step is crucial for developing novel and specific therapeutic approaches that could ultimately counteract age-related tissue dysfunction allowing a healthy aging.

Labels: MiParea: mt-Structure;fission;fusion, Exercise physiology;nutrition;life style  Pathology: Aging;senescence 

Tissue;cell: Skeletal muscle 

Event: Poster 

Affiliations

Romanello V(1,2), Sandri M(1,2)

# Venetian Inst Molecular Medicine, Padova, Italy

# Dept Biomedical Sc, Univ Padova, Italy