Mendes 2022 Mitochondrion
Mendes D, Peixoto F, Oliveira MM, Andrade PB, Videira RA (2022) Mitochondria research and neurodegenerative diseases: On the track to understanding the biological world of high complexity. https://doi.org/10.1016/j.mito.2022.05.001 |
Β» Mitochondrion 65:67-79. PMID: 35623557 Open Access
Mendes Daniela, Peixoto Francisco, Oliveira Maria M, Andrade Paula B, Videira Romeu A (2022) Mitochondrion
Abstract: From the simple unicellular eukaryote to the highly complex multicellular organism like Human, mitochondrion emerges as a ubiquitous player to ensure the organism's functionality. It is popularly known as "the powerhouse of the cell" by its key role in ATP generation. However, our understanding of the physiological relevance of mitochondria is being challenged by data obtained in different fields. In this review, a short history of the mitochondria research field is presented, stressing the findings and questions that allowed the knowledge advances, and put mitochondrion as the main player of safeguarding organism life as well as a key to solve the puzzle of the neurodegenerative diseases. β’ Keywords: Alzheimerβs and Parkinsonβs diseases, Cellular networks connectivity, Mitochondria 3-D architecture, Mitochondria-targeted therapy, Mitochondrial bioenergetic β’ Bioblast editor: Plangger M
Labels: MiParea: Respiration
Pathology: Alzheimer's, Neurodegenerative, Parkinson's
HRR: Oxygraph-2k
2022-11