Acyl-CoA oxidase

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Acyl-CoA oxidase

Description

Acyl-CoA oxidase is considered as a rate-limiting step in peroxysomal β-oxidation, which carries out few β-oxidation cycles, thus shortening very-long-chain fatty acids (>C20). Electrons are directly transferred from FADH2 to O2 with the formation of H2O2.


Reference: Speijer 2016 Biochem J

  • Small GM, Burdett K, Connock MJ (1985) A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase. Biochem J 227:205-10. - »Bioblast link«
  • Speijer D (2016) Being right on Q: shaping eukaryotic evolution. Biochem J 473:4103-27. - »Bioblast link«
  • Vamecq J, Schepers L, Parmentier G, Mannaerts GP (1987) Inhibition of peroxisomal fatty acyl-CoA oxidase by antimycin A. Biochem J 248:603-7. - »Bioblast link«
  • Zeng J, Deng S, Wang Y, Li P, Tang L, Pang Y (2017) Specific inhibition of acyl-CoA oxidase-1 by an acetylenic acid improves hepatic lipid and reactive oxygen species (ROS) metabolism in rats fed a high fat diet. J Biol Chem 292:3800-9. - »Bioblast link«


MitoPedia topics: Enzyme