Difference between revisions of "NS e-input"
Β |
|||
(2 intermediate revisions by one other user not shown) | |||
Line 1: | Line 1: | ||
{{MitoPedia | {{MitoPedia | ||
|abbr=NS, CI<small>&</small>II | |abbr=NS, CI<small>&</small>II | ||
|description='''NS e-input''' or the [[NS-pathway control state]] is electron input from a combination of substrates for the [[N-pathway control state]] and [[S-pathway control state]] through Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction]]. NS e-input corresponds to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[ | |description='''NS e-input''' or the [[NS-pathway control state]] is electron input from a combination of substrates for the [[N-pathway control state]] and [[S-pathway control state]] through Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction]]. NS e-input corresponds to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[Electron transfer pathway]]. In [[Mitochondrial preparations|mt-preparations]], NS e-input requires addition not only of NADH- (N-) linked substrates (pyruvate&malate or glutamate&malate), but of succinate (S) simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: [[Additive effect of convergent electron flow]]. | ||
|info=[[Gnaiger | |info=[[Gnaiger 2020 BEC MitoPathways]], [[Gnaiger 2009 Int J Biochem Cell Biol]] | ||
}} | }} | ||
{{MitoPedia concepts | {{MitoPedia concepts | ||
Line 8: | Line 8: | ||
}} | }} | ||
== From CI<small>&</small>II e-input to NS e-input == | == From CI<small>&</small>II e-input to NS e-input == | ||
::::Β» [[ | ::::Β» [[Electron_transfer-pathway_state#Terminology:_from_CI-_and_CII-linked_to_N_and_S|Terminology]] |
Latest revision as of 18:49, 1 January 2021
Description
NS e-input or the NS-pathway control state is electron input from a combination of substrates for the N-pathway control state and S-pathway control state through Complexes CI and CII simultaneously into the Q-junction. NS e-input corresponds to TCA cycle function in vivo, with convergent electron flow through the Electron transfer pathway. In mt-preparations, NS e-input requires addition not only of NADH- (N-) linked substrates (pyruvate&malate or glutamate&malate), but of succinate (S) simultaneously, since metabolite depletion in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: Additive effect of convergent electron flow.
Abbreviation: NS, CI&II
Reference: Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
MitoPedia concepts:
MiP concept,
SUIT concept
From CI&II e-input to NS e-input
- Β» Terminology