Difference between revisions of "Bioblast"
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=== [[Bioblast alert]] 2016(01): 2016-02-10 === | === [[Bioblast alert]] 2016(01): 2016-02-10 === | ||
[[Image:MitoPedia.jpg|left| | [[Image:MitoPedia.jpg|left|140px|link=http://www.bioblast.at/index.php/MitoPedia|MitoPedia]] | ||
Dear colleagues: | |||
<br /><br /> | <br /><br /> | ||
Over the past years, there was a continuous struggle to find a language for translating our experimental findings obtained from [[SUIT protocols]] into | Over the past years, there was a continuous struggle to find a language for translating our experimental findings obtained from [[SUIT protocols]] into shared information. | ||
<br /><br /> | <br /><br /> | ||
Still | Still the state-of-the-art terminology and less consistent variations are not commonly understandable. Various efforts, including serial editions of ‘MitoPathways’ ([[Gnaiger 2014 MitoPathways |The Blue Book]]), were basically a failure: We cannot expect an audience to grasp our message, if we say ‘Complex I’ – yet actually having in mind the pathway from NADH-linked substrates to CI - CIII - CIV. Should we rather say CI-CIII-CIV-linked ??? | ||
<br /><br /> | <br /><br /> | ||
Or even worse ( | Or even worse (a mistake): We say ‘[[Complex I&II-linked substrate state |CI<small>&</small>II]]’ (or a previous mistake: ‘CI+II’: ''are the two enzyme complexes added?''), when we actually measure electron transfer linked to CI<small>&</small>II - CIII - CIV !!! | ||
<br /><br /> | <br /><br /> | ||
The cartoons are clear: [[Respiratory complexes]]. The words are not. | |||
<br /><br /> | <br /><br /> | ||
I invite you to challenge fundamentally the way we think and talk and write about our results. To drop the CI-linked, CII-linked, CI<small>&</small>II (CI+II) terminology is not trivial. It is a necessary step. We, you, many colleagues will not like to make a real change. Change is not only important but necessary to make our field of mitochondrial physiology less confusing and more attractive. Perhaps we can even attain a deeper understanding among the involved specialists - the Bioblasts. | |||
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'''Don't say ‘Complex I’ when it IS NOT JUST Complex I'''. Why talk about a subset of '''enzyme complexes''' when we have much more '''complicated pathways''' in mind, fuelled by a selection and combination of specific '''substrate types'''. Stop for a moment. If you agree, take a look at new entries into MitoPedia prepared during the past months. | |||
<br /> | <br /> | ||
:» Substrate types and pathway | :» [[Substrate types |Substrate types and pathway types]]<br /> | ||
:» [[Categories of SUIT protocols]]<br /> | :» [[Categories of SUIT protocols]]<br /> | ||
:» [[SUIT protocol names]]<br /> | :» [[SUIT protocol names]]<br /> | ||
<br /> | <br /> | ||
I am looking forward to your feedback. Your input will be essential to find a common language for communication with the people whom we want to reach with our research in mitochondrial physiology. | I am looking forward to your feedback. Your input will be essential to find a common language for communication with the people whom we want to reach with our research in mitochondrial physiology. Join a new '''quality management of reporting''' to forge results into useful knowlege. Messages of mitochondrial physiology deserve to be understood on a global scale, in support of various health systems in general and mitochondrial organizations in particular. Lets cooperate in an effort to encourage our modern society to become and stay [[MitoFit]]. | ||
</big><br /> | </big><br /> | ||
Revision as of 00:26, 11 February 2016
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Bioblast alert 2016(01): 2016-02-10
Over the past years, there was a continuous struggle to find a language for translating our experimental findings obtained from SUIT protocols into shared information.
Still the state-of-the-art terminology and less consistent variations are not commonly understandable. Various efforts, including serial editions of ‘MitoPathways’ (The Blue Book), were basically a failure: We cannot expect an audience to grasp our message, if we say ‘Complex I’ – yet actually having in mind the pathway from NADH-linked substrates to CI - CIII - CIV. Should we rather say CI-CIII-CIV-linked ???
Or even worse (a mistake): We say ‘CI&II’ (or a previous mistake: ‘CI+II’: are the two enzyme complexes added?), when we actually measure electron transfer linked to CI&II - CIII - CIV !!!
The cartoons are clear: Respiratory complexes. The words are not.
I invite you to challenge fundamentally the way we think and talk and write about our results. To drop the CI-linked, CII-linked, CI&II (CI+II) terminology is not trivial. It is a necessary step. We, you, many colleagues will not like to make a real change. Change is not only important but necessary to make our field of mitochondrial physiology less confusing and more attractive. Perhaps we can even attain a deeper understanding among the involved specialists - the Bioblasts.
Don't say ‘Complex I’ when it IS NOT JUST Complex I. Why talk about a subset of enzyme complexes when we have much more complicated pathways in mind, fuelled by a selection and combination of specific substrate types. Stop for a moment. If you agree, take a look at new entries into MitoPedia prepared during the past months.
I am looking forward to your feedback. Your input will be essential to find a common language for communication with the people whom we want to reach with our research in mitochondrial physiology. Join a new quality management of reporting to forge results into useful knowlege. Messages of mitochondrial physiology deserve to be understood on a global scale, in support of various health systems in general and mitochondrial organizations in particular. Lets cooperate in an effort to encourage our modern society to become and stay MitoFit.
With best wishes and kind regards,
Erich
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