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User talk:Beno Marija/MitO2 Kit Produktseite

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User talk:Beno Marija/MitO2 Kit Produktseite

O2k-Catalogue

Description Cell permeable compound - MitO2-Kit, 2 vials; for a final volume of 35 mg (25mg NVP118 + 10mg NVP161)
Product ID (##)
Type O2k
Link NVP118, NVP161
Image
MiR05-Kit label.png

Compounds

Cell permeable compound - MitO2-Kit

Publications in the MiPMap
O2k-Protocols
Cell permeable compound - MitO2-Kit.

» Bioblast pdf » Versions

Oroboros (2019-03-01) Mitochondr Physiol Network

Abstract: Gnaiger E, Laner V, Passrugger M, NeuroVive Pharmaceutical AB (2019) cell permeable compound - MitO2-Kit. Mitochondr Physiol Network 24.03(01):1-2.

(##) The cell permeable compound MitO2-Kit is the first generation of NeuroVive Pharmaceutical AB's succinate/malonate prodrugs and was developed to stimulate and inhibit Complex II of the respiratory electron transfer system in intact cells, and will expand the toolbox for evaluating the role of mitochondria in disease.

» Product: Oroboros O2k, O2k-Catalogue

Keywords: Mit02-Kit

O2k-Network Lab: AT_Innsbruck_Oroboros, NeuroVive


Compounds of MitO2-Kit

The MitO2-Kit is composed of equal quantities of the following Compounds:
Description: Succinate prodrug: C10H14O8, Molecular weight 262,2g.mol-1
Aliquots per 25 mg


Description: Malonate prodrug: C9H12O8, Molecular weight 248,2g.mol-1
Aliquots per 10 mg


  • Reference:
Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317. »Bioblast link« - Original publication introducing MitO2.


Expiry date of MitO2

  1. The stability of compounds in DMSO solution at room temperature is for at least 24h. The estimated stability of the compounds in DMSO at -20 would be weeks. The aliquoted 118 and 161 are stable at -20 for 6 months+. The powder is likely stable for much longer.
  • CAS-Number 1592635-33-0 for NV-118
  • CAS-Number 1432752-62-9 for NV-161


Labels: MiParea: Instruments;methods 





HRR: O2k-Protocol 

O2k-chemicals and media