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| {{MitoPedia
| | #REDIRECT [[Noncoupled respiration]] |
| |description=The '''uncoupled''' part of '''respiration''' in ''[[state P]]'' pumps protons to compensate for intrinsic uncoupling, which is a property of:
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| (a) the inner mt-membrane ([[proton leak]]),
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| (b) the proton pumps ([[proton slip]]; decoupling), and
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| (c) is regulated by molecular uncouplers ([[uncoupling protein]], UCP1).
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| Uncoupled and [[dyscoupled respiration]] are summarized as [[LEAK respiration]]. In contrast, [[non-coupled respiration]] is induced experimentally for evaluation of [[ETS capacity]].
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| |info=[[MiPNet12.15]], [[MiPNet10.04]]
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| |type=Respiration
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| }}
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| {{MitoPedia topics
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| |mitopedia topic=Uncoupler
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| |type=Respiration
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| {{Labeling
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| |discipline=Mitochondrial Physiology
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| |enzymes=Uncoupler Protein
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| |topics=Respiration; OXPHOS; ETS Capacity, Coupling; Membrane Potential
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| |type=Respiration
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| }}
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| The uncoupled part of respiration in state ''P'' is larger than LEAK respiration evaluated in state ''L'' after inhibition of [[ATP synthase]] or [[adenine nucleotide translocase]]. This is due to the increase of mt-membrane potential in state ''L'' versus ''P'', causing a corresponding increase of the proton leak driven by the higher proton motive force. As an approximation, however, the difference ''E''-''L'' yields an estimate of the physiological scope of uncoupling, or the pathological scope of dyscoupling.
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