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Steps and respiratory states
Step
|
State
|
Pathway
|
Q-junction
|
Comment - Events (E) and Marks (M)
|
1PM
|
PML(n)
|
N
|
CI
|
1PM
|
2D
|
PMP
|
N
|
CI
|
1PM;2D
|
2c
|
PMcP
|
N
|
CI
|
1PM;2D;2c
|
3U
|
PME
|
N
|
CI
|
1PM;2D;3U
|
4G
|
PGME
|
N
|
CI
|
1PM;2D;3U;4G
|
5S
|
PGMSE
|
NS
|
CI&II
|
1PM;2D;3U;4G;5S
- Respiratory stimulation by simultaneous action of type N substrates & succinate, with convergent electron flow in the NS-pathway for reconstitution of TCA cycle function.
- Noncoupled electron transfer state, ET state, with ET capacity E.
|
6Oct
|
OctPGMSE
|
FNS
|
FAO&CI&II
|
1PM;2D;3U;4G;5S;6Oct
- Respiratory stimulation by simultaneous action of the F-pathway, N-pathway, and S-pathway, with convergent electron flow in the FNS-pathway for reconstitution of TCA cycle function and additive or inhibitory effect of F.
- Noncoupled electron transfer state, ET state, with ET capacity E.
|
7Rot
|
SE
|
S
|
CII
|
1PM;2D;3U;4G;5S;6Oct;7Rot
|
8Gp
|
SGpE
|
SGp
|
CII&GpDH
|
1PM;2D;3U;4G;5S;6Oct;7Rot;8Gp
- Respiratory stimulation by action of succinate and glycerophosphate, Gp, with convergent electron flow in the SGp-pathway (CII&GpDH-linked pathway to the Q-junction).
- Noncoupled electron transfer state, ET state, with ET capacity E.
|
9Ama
|
ROX
|
|
|
1PM;2D;3U;4G;5S;6Oct;7Rot;8Gp;9Ama
- Rox is the residual oxygen consumption in the ROX state, due to oxidative side reactions, estimated after addition of antimycin A (inhibitor of CIII). Rox is subtracted from oxygen flux as a baseline for all respiratory states, to obtain mitochondrial respiration (mt).
|
Step
|
Respiratory state
|
Pathway control
|
ET-Complex
|
Comment
|
## AsTm
|
AsTmE
|
CIV
|
CIV
|
|
## Azd
|
CHB
|
|
|
|
- Bioblast links: SUIT protocols - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Coupling control
- » Coupling control state
- » ET capacity
- » OXPHOS capacity
- » LEAK respiration
- Pathway control
- » Electron transfer pathway
- » Fatty acid oxidation pathway control state, F
- » NADH electron transfer-pathway state, N
- » Succinate pathway control state, S
- » NS-pathway control state, NS
- » Glycerophosphate pathway control state, Gp
- » Complex IV single step, CIV
- » Anaplerotic pathway control state
- Main fuel substrates
- » Glutamate, G
- » Glycerophosphate, Gp
- » Malate, M
- » Octanoylcarnitine, Oct
- » Pyruvate, P
- » Succinate, S
- Glossary
- » List of SUIT states
- » SUIT concept