|
|
| (11 intermediate revisions by 3 users not shown) |
| Line 1: |
Line 1: |
| The '''succinate-linked respiration or S-pathway (succinate-induced respiratory state; previously used nomenclature: CII-linked respiration; SRot; see [Gnaiger 2009 Int J Biochem Cell Biol])''' is achieved with succinate '''(S)''' as the single substrate, at ET-pathway-level pathway level 3. S supports electron flux through '''mitochondrial''' Complex II '''(succinate dehydrogenase)''' to CII-bound flavin adenine dinucleotide (FADH2) to Q. Inhibition of Complex I '''(CI)''' by rotenone (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of succinate dehydrogenase. After inhibition of CI by '''Rot''', the NADH-linked dehydrogenases become inhibited by the redox shift from NAD+ to NADH. Succinate dehydrogenase is activated by succinate and ATP, which explains in part the time-dependent increase of respiration in isolated mitochondria after addition of rotenone (first), succinate and ADP.
| | [[Image:BB-Bioblast.jpg|left|40px|link=Bioblast:About|Bioblast wiki]] |
| : | | == Popular Bioblast page == |
| The '''S-pathway''' is induced in mt-preparations by addition of succinate&rotenone (Complex I inhibitor). Succinate is the direct substrate of Complex II (succinate dehydrogenase). '''In this case,''' only Complex III and Complex IV are involved in pumping protons from the matrix (P-phase) to the N-phase with a ~P/O ratio of 1.75 (P/O2 = 3.5).
| | ::: [[Succinate pathway]] has been accessed more than |
| | | ::::* 10,000 times (2019-12-12) |
| ~''The changes are in'' '''bold'''. [[User:Bastosa|Bastosa]] ([[User talk:Bastosa|talk]]) 14:36, 24 July 2018 (CEST)
| |
