Difference between revisions of "Talk:BAM15"

Revision as of 14:59, 21 May 2014 (view source) Bauer Christiane (talk \| contribs) (Created page with "'''2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine''' is a protonophore or uncoupler of oxidative phosphorylation detected in a screen fo...")		Latest revision as of 05:35, 3 December 2018 (view source) Gnaiger Erich (talk \| contribs) m (Gnaiger Erich moved page Talk:BAM 15 to Talk:BAM15)
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	'''2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine''' is a protonophore or [[uncoupler]] of oxidative phosphorylation detected in a screen for uncoupling agents exerting less toxicity than commonly used uncouplers and first described by [[Kennwood 2013 Mol MeTAB\| Kennwood et al. 2013]].
	In their comparative study using BAM 15 and [[FCCP]] it was shown to increase oxygen flux to a similar extent as the classical uncoupler, to display a much broader range of concentrations inducing maximum respiration, to elicit no formation of H<sub>2</sub>O<sub>2</sub>, to leave cellular membrane potential unaffected, and to ultimately exert less cytotoxicity.

Latest revision as of 05:35, 3 December 2018