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Property "Has-20abstract" (as page type) with input value "Understanding-20the-20mitochondrial-20processes-20that-20contribute-20to-20body-20energy-20metabolism-20may-20provide-20an-20attractive-20therapeutic-20target-20for-20obesity-20and-20co-2Dmorbidities.-20Here-20we-20investigated-20whether-20intermittent-20dietary-20supplementation-20with-20conjugated-20linoleic-20(CLA,-2018:2n-2D6),-20docosahexaenoic-20(22:6n-2D3,-20DHA)-20and-20eicosapentaenoic-20(20:5n-2D3,-20EPA)-20acids,-20either-20alone-20or-20in-20combination,-20changes-20body-20metabolism-20associated-20with-20mitochondrial-20functions-20in-20the-20brain,-20liver,-20skeletal-20muscle-20and-20brown-20adipose-20tissue-20(BAT).-20Male-20C57Bl-2F6-20mice-20were-20spanided-20into-20groups:-20CLA-20(50-25-20cis-2D9,-20trans-2D11-3B-2050-25-20trans-2D10,-20cis-2D12),-20EPA-2FDHA-20(64-25-20EPA-3B-2028-25-20DHA),-20CLA-20plus-20EPA-2FDHA-20or-20control-20(linoleic-20acid).-20Each-20mouse-20received-203-20g-2Fkg-20b.w.-20of-20the-20stated-20oil-20by-20gavage-20on-20alternating-20days-20for-2060-20days.-20Dietary-20supplementation-20with-20CLA-20or-20EPA-2FDHA-20increased-20body-20VO-3Csub-3E2-3C-2Fsub-3E-20consumption,-20VCO-3Csub-3E2-3C-2Fsub-3E-20production-20and-20energy-20expenditure,-20being-20fish-20oil-20(FO)-20the-20most-20potent-20even-20in-20combination-20with-20CLA.-20Inspanidually,-20both-20oils-20reduced-20mitochondrial-20density-20in-20BAT.-20CLA-20supplementation-20alone-20also-20a)-20elevated-20the-20expression-20of-20uncoupling-20proteins-20in-20soleus,-20liver-20and-20hippocampus-20and-20the-20uncoupling-20activity-20in-20the-20last-20two,-20ad-20this-20effect-20was-20associated-20with-20reduced-20hydrogen-20peroxide-20production-20in-20hippocampus-3B-20b)-20increased-20proteins-20related-20to-20mitochondrial-20fission-20in-20liver.-20EPA-2FDHA-20supplementation-20alone-20also-20a)-20induced-20mitochondrial-20biogenesis-20in-20liver,-20soleus-20and-20hippocampus-20associated-20with-20increased-20expression-20of-20PGC1-2Dα-3B-20b)-20induced-20proteins-20related-20to-20mitochondrial-20fusion-20in-20the-20liver,-20and-20fission-20and-20fusion-20in-20the-20hippocampus.-20Therefore,-20this-20study-20shows-20changes-20on-20mitochondrial-20mechanisms-20induced-20by-20CLA-20and-2For-20EPA-2FDHA-20that-20can-20be-20associated-20with-20elevated-20body-20energy-20expenditure." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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