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Property "Has-20abstract" (as page type) with input value "The-20prevalence-20of-20obesity-20is-20increasing-20worldwide,-20causing-20a-20subsequent-20increase-20in-20insulin-20resistance-20(IR),-20metabolic-20disorders,-20and-20cardiovascular-20diseases.-20Although-20these-20conditions-20significantly-20impact-20both-20the-20inspanidual-20and-20society,-20their-20etiologies-20have-20not-20been-20discovered,-20inhibiting-20potential-20prevention-20and-20treatment.-20Alterations-20to-20mitochondrial-20metabolism-20are-20implicated-20in-20the-20development-20of-20IR-20and-20progression-20to-20Type-202-20Diabetes-20(T2D),-20raising-20the-20need-20for-20an-20investigation-20of-20mitochondrial-20metabolism-20in-20skeletal-20muscle.-20Understanding-20metabolism-20on-20an-20inspanidual-20substrate-20basis-20within-20a-20model-20system-20enables-20identification-20of-20each-20nutrient’s-20contribution-20to-20respiration-20and-20potential-20mitochondrial-20dysfunction.-20As-20such,-20the-20purpose-20of-20this-20investigation-20was-20to-20characterize-20mitochondrial-20metabolism-20and-20determine-20mitochondrial-20respiratory-20control-20in-20L6-20rat-20myoblasts.-20High-2Dresolution-20respirometry-20and-20three-20Substrate-2DUncoupler-2DInhibitor-2DTitration-20(SUIT)-20protocols-20were-20used-20to-20examine-20respiration.-20Mitochondrial-20capacity-20was-20not-20limited-20by-20the-20electron-20transfer-20system,-20although-20the-20presence-20of-20multiple-20substrates-20potentially-20flooded-20the-20Q-2Djunction,-20resulting-20in-20lower-20respiratory-20control-20and-20indicating-20the-20presence-20of-20a-20potential-20limiting-20factor.-20In-20sum,-20L6-20myoblasts-20exhibit-20no-20overt-20defects-20in-20mitochondrial-20metabolism,-20but-20may-20have-20a-20propensity-20for-20substrate-20overload,-20thereby-20limiting-20respiration." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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