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Property "Has-20abstract" (as page type) with input value "The-20insulin-2Dlike-20growth-20factor-20(IGF)-20network-20with-20its-20main-20receptors-20insulin-2Dlike-20growth-20factor-20receptor-201-20(IGF1R)-20and-20insulin-20receptor-20(INSR)-20is-20of-20major-20importance-20for-20cancer-20initiation-20and-20progression.-20To-20date-20clinical-20studies-20targeting-20this-20network-20were-20disappointing-20and-20call-20for-20thorough-20analysis-20of-20the-20IGF-20network-20in-20cancer-20models.-20We-20highlight-20the-20oncogenic-20effects-20controlled-20by-20IGF1R-20and-20INSR-20in-20prostate-20cancer-20cells-20and-20show-20similarities-20as-20well-20as-20differences-20after-20receptor-20knockdown-20(KD).-20In-20PC3-20prostate-20cancer-20cells-20stably-20transduced-20with-20inducible-20short-20hairpin-20RNAs-20(shRNA)-20targeting-20IGF1R-20or-20INSR-20attenuated-20cell-20growth-20and-20proliferation-20ultimately-20driving-20cells-20into-20apoptosis.-20IGF1R-20KD-20triggered-20rapid-20and-20strong-20anti-2Dproliferative-20and-20pro-2Dapoptotic-20responses-20whereas-20these-20effects-20were-20less-20pronounced-20and-20delayed-20after-20INSR-20KD.-20Downregulation-20of-20the-20anti-2Dapoptotic-20proteins-20Mcl-2D1-20and-20survivin-20was-20observed-20in-20both-20knockdowns-20whereas-20IGF1R-20KD-20also-20attenuated-20expression-20of-20pro-2Dsurvival-20proteins-20Bcl-2D2-20and-20Bcl-2DxL.-20Receptor-20KD-20induced-20cell-20death-20involved-20autophagy-20in-20particular-20upon-20IGF1R-20KD,-20however-20no-20difference-20in-20mitochondrial-20energy-20metabolism-20was-20observed.-20In-20a-20mouse-20xenograft-20model-20induction-20of-20IGF1R-20or-20INSR-20KD-20after-20tumor-20establishment-20eradicated-20most-20of-20the-20tumors.-20After-2020-20days-20of-20receptor-20KD-20tumor-20cells-20were-20found-20only-20in-201-2F14-20IGF1R-20and-203-2F14-20INSR-20KD-20tumor-20remnants.-20Collectively,-20our-20data-20underline-20the-20oncogenic-20functions-20of-20IGF1R-20and-20INSR-20in-20prostate-20cancer-20namely-20growth,-20proliferation-20and-20survival-20-27-27in-20vitro-27-27-20as-20well-20as-20-27-27in-20vivo-27-27-20and-20identify-20Mcl-2D1-20and-20survivin-20as-20important-20mediators-20of-20inhibitory-20and-20apoptotic-20effects." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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