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Property "Has-20abstract" (as page type) with input value "The-20impact-20of-20sexual-20dimorphism-20and-20mitophagy-20on-20hepatic-20mitochondrial-20adaptations-20during-20the-20treatment-20of-20steatosis-20with-20physical-20activity-20are-20largely-20unknown.-20Here,-20we-20tested-20if-20deficiencies-20in-20liver-2Dspecific-20PGC-2D1a,-20a-20transcriptional-20co-2Dactivator-20of-20biogenesis,-20and-20BNIP3,-20a-20mitophagy-20regulator,-20would-20impact-20hepatic-20mitochondrial-20adaptations-20(respiratory-20capacity,-20H-3Csub-3E2-3C-2Fsub-3EO-3Csub-3E2-3C-2Fsub-3E-20production,-20mitophagy)-20to-20a-20high-2Dfat-20diet-20(HFD)-20and-20HFD-20plus-20physical-20activity-20via-20voluntary-20wheel-20running-20(VWR)-20in-20both-20sexes.-20Male-20and-20female-20wild-20type-20(WT),-20liver-2Dspecific-20PGC-2D1a-20heterozygote-20(LPGC-2D1a)-20and-20BNIP3-20null-20mice-20were-20thermoneutral-20housed-20(29-2D31°C)-20and-20spanided-20into-20three-20groups:-20sedentary-20-2D-20low-20fat-20diet-20(LFD),-2016-20weeks-20of-20(HFD),-20or-2016-20weeks-20of-20HFD-20with-20VWR-20for-20the-20final-208-20weeks-20(HFD+VWR)-20(n=5-2D7-2Fsex-2Fgroup).-20HFD-20did-20not-20impair-20mitochondrial-20respiratory-20capacity-20or-20coupling-20in-20any-20group,-20however-20HFD+VWR-20significantly-20increased-20maximal-20respiratory-20capacity-20only-20in-20WT-20and-20PGC-2D1a-20females.-20Males-20required-20VWR-20to-20elicit-20mitochondrial-20adaptations-20that-20were-20inherently-20present-20in-20sedentary-20females-20including-20greater-20mitochondrial-20coupling-20efficiency-20and-20reduced-20H-3Csub-3E2-3C-2Fsub-3EO-3Csub-3E2-3C-2Fsub-3E-20production.-20Females-20had-20overall-20reduced-20markers-20of-20mitophagy,-20steatosis,-20and-20liver-20damage.-20Steatosis-20and-20markers-20of-20liver-20injury-20were-20present-20in-20sedentary-20male-20mice-20on-20the-20HFD-20and-20were-20effectively-20reduced-20with-20VWR-20despite-20no-20resolution-20of-20steatosis.-20Overall,-20reductions-20in-20PGC-2D1a-20and-20loss-20of-20BNIP3-20only-20modestly-20impacted-20mitochondrial-20adaptations-20to-20HFD-20and-20HFD+VWR-20with-20the-20biggest-20effect-20seen-20in-20BNIP3-20females.-20In-20conclusion,-20hepatic-20mitochondrial-20adaptations-20to-20HFD-20and-20treatment-20of-20HFD-2Dinduced-20steatosis-20with-20VWR-20are-20more-20dependent-20on-20sex-20than-20PGC-2D1a-20or-20BNIP3." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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