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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "The-20decline-20in-20fat-20oxidation-20at-20higher-20power-20outputs-20of-20exercise-20is-20a-20complex-20interaction-20between-20several-20mechanisms,-20however-20the-20influence-20of-20mitochondrial-20bioenergetics-20in-20this-20process-20remains-20elusive.-20Therefore,-20using-20permeabilized-20muscle-20fibers-20from-20mouse-20skeletal-20muscle,-20we-20aimed-20to-20determine-20if-20acute-20exercise-20altered-20mitochondrial-20sensitivity-20to-201)-20adenosine-20diphosphate-20(ADP)-20and-20inorganic-20phosphate-20(Pi),-20or-202)-20carnitine-20palmitoyltransferase-2DI-20(CPT-2DI)-20independent-20(palmitoylcarnitine,-20PC)-20and-20dependent-20(palmitoyl-2DCoA-20(P-2DCoA),-20malonyl-2DCoA-20(M-2DCoA),-20and-20L-2Dcarnitine)-20substrates,-20in-20an-20intensity-2Ddependent-20manner.-20As-20the-20apparent-20ADP-20-3Csub-3EKm-3C-2Fsub-3E-20increased-20to-20a-20similar-20extent-20following-20low-20(LI)-20and-20high-20(HI)-20intensity-20exercise-20compared-20to-20sedentary-20(SED)-20animals,-20and-20Pi-20sensitivity-20was-20unaltered-20by-20exercise,-20regulation-20of-20phosphate-20provision-20likely-20does-20not-20contribute-20to-20the-20well-2Destablished-20intensity-2Ddependent-20shift-20in-20substrate-20utilization.-20Mitochondrial-20sensitivity-20to-20PC-20and-20P-2DCoA-20were-20not-20influenced-20by-20exercise,-20while-20M-2DCoA-20sensitivity-20was-20attenuated-20similarly-20following-20LI-20and-20HI.-20In-20contrast,-20CPT-2DI-20sensitivity-20to-20L-2Dcarnitine-20was-20only-20altered-20following-20HI,-20as-20HI-20exercise-20attenuated-20L-2Dcarnitine-20sensitivity-20by-20~40-25.-20Moreover,-20modelling-20the-20-27-27in-20vivo-27-27-20concentrations-20of-20L-2Dcarnitine-20and-20P-2DCoA-20during-20exercise-20suggest-20that-20CPT-2DI-20flux-20is-20~25-25-20lower-20following-20HI,-20attributed-20equally-20to-20reductions-20in-20L-2Dcarnitine-20content-20and-20L-2Dcarnitine-20sensitivity.-20Altogether,-20these-20data-20further-20implicate-20CPT-2DI-20flux-20as-20a-20key-20event-20influencing-20metabolic-20interactions-20during-20exercise,-20as-20a-20decline-20in-20L-2Dcarnitine-20sensitivity-20in-20addition-20to-20availability-20at-20higher-20power-20outputs-20could-20impair-20mitochondrial-20fatty-20acid-20oxidation.-0A-0A-3Csmall-3EĀ©2019-20The-20Author(s).-3C-2Fsmall-3E" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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