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Property "Has-20abstract" (as page type) with input value "Sepsis-2Dinduced-20hepatic-20dysfunction-20is-20considered-20as-20an-20independent-20risk-20factor-20of-20multiple-20organ-20dysfunction-20syndrome-20(MODS)-20and-20death.-20Mitophagy,-20a-20selective-20form-20of-20autophagy,-20plays-20a-20major-20role-20in-20sepsis-2Dinduced-20organ-20damage.-20We-20have-20demonstrated-20that-20hydrogen-20gas-20(H-3Csub-3E2-3C-2Fsub-3E),-20a-20selective-20antioxidant,-20exerts-20protective-20effects-20in-20septic-20mice.-20Here,-20we-20hypothesize-20that-20the-20therapeutic-20effects-20of-20H-3Csub-3E2-3C-2Fsub-3E-20on-20septic-20animals-20with-20liver-20damages-20may-20be-20exerted-20through-20regulation-20of-20the-20Fun14-20domain-2Dcontaining-20protein-201-20(FUDNC1)-2Dinduced-20mitophagy-20pathway.-20Male-20C57BL-2F6J-20mice-20were-20subjected-20to-20sham-20or-20cecal-20ligation-20and-20puncture-20(CLP)-20operation-20and-20treated-20with-202-25-20H-3Csub-3E2-3C-2Fsub-3E-20gas-20inhalation-20for-203 h-20starting-20at-201 h-20after-20sham-20or-20CLP-20surgery.-20To-20verify-20the-20role-20of-20FUNDC1,-20the-20cell-2Dpenetrating-20peptide-20P-20(NH2-2DGRKKRRQRRRPQDYESDDESYEVLDLTEY-2DCOOH)-20(1 mg-2Fkg)-20that-20functions-20as-20a-20FUNDC1-20inhibitor-20was-20intraperitoneally-20injected-20into-20mice-2024 h-20before-20the-20sham-20or-20CLP-20operation.-20To-20evaluate-20the-20severity-20of-20septic-20liver-20injury,-20the-207-2Dday-20survival-20rate,-20liver-20histopathologic-20score,-20alanine-20aminotransferase-20(ALT)-20and-20aspartate-20aminotransferase-20(AST)-20levels,-20respiration-20control-20ratio-20(RCR),-20and-20FUDNC1,-20P-2D18-2DFUDNC1,-20P62,-20LC3B-2DII,-20Tim23,-20and-20caspase-2D1-20levels-20were-20evaluated-20after-20the-20sham-20or-20CLP-20operation.-20The-20results-20demonstrated-20that-202-25-20H-3Csub-3E2-3C-2Fsub-3E-20gas-20inhalation-20resulted-20in-20an-20increase-20in-20the-207-2Dday-20survival-20rate,-20ALT-20and-20AST-20levels,-20RCR,-20and-20P62-20and-20LC3B-2DII-20expression-20but-20decreased-20the-20histological-20score-20and-20FUDNC1,-20P-2D18-2DFUDNC1,-20Tim23,-20and-20caspase-2D1-20levels-20after-20sepsis.-20However,-20no-20significant-20differences-20were-20reported-20between-20the-20CLP + peptide-20P-20and-20CLP + H-3Csub-3E2-3C-2Fsub-3E + peptide-20P-20groups.-20These-20observations-20indicate-20that-202-25-20H-3Csub-3E2-3C-2Fsub-3E-20gas-20inhalation-20for-203 h-20may-20serve-20as-20an-20effective-20therapeutic-20strategy-20for-20sepsis-2Dinduced-20liver-20injury-20through-20the-20regulation-20of-20FUNDC1-2Ddependent-20mitophagy.-0A-0A-3Csmall-3ECopyright-20©-202019-20Elsevier-20B.V.-20All-20rights-20reserved.-3C-2Fsmall-3E" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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