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Property "Has-20abstract" (as page type) with input value "Sarcopenia-20and-20exercise-20intolerance-20are-20major-20contributors-20to-20reduced-20quality-20of-20life-20in-20the-20elderly-20for-20which-20there-20are-20few-20effective-20treatments.-20We-20tested-20whether-20enhancing-20mitochondrial-20function-20and-20reducing-20mitochondrial-20oxidant-20production-20with-20SS-2D31-20(elamipretide)-20could-20restore-20redox-20balance-20and-20improve-20skeletal-20muscle-20function-20in-20aged-20mice.-20Young-20(5-20mo)-20and-20aged-20(26-20mo)-20female-20C57BL-2F6Nia-20mice-20were-20treated-20for-208-2Dweeks-20with-203mg-2Fkg-2Fday-20SS-2D31.-20Mitochondrial-20function-20was-20assessed-20-27-27in-20vivo-27-27-20using-20-3Csup-3E31-3C-2Fsup-3EP-20and-20optical-20spectroscopy.-20SS-2D31-20reversed-20age-2Drelated-20decline-20in-20maximum-20mitochondrial-20ATP-20production-20(ATPmax)-20and-20coupling-20of-20oxidative-20phosphorylation-20(P-2FO).-20Despite-20the-20increased-20-27-27in-20vivo-27-27-20mitochondrial-20capacity,-20mitochondrial-20protein-20expression-20was-20either-20unchanged-20or-20reduced-20in-20the-20treated-20aged-20mice-20and-20respiration-20in-20permeabilized-20gastrocnemius-20(GAS)-20fibers-20was-20not-20different-20between-20the-20aged-20and-20aged+SS-2D31-20mice.-20Treatment-20with-20SS-2D31-20also-20restored-20redox-20homeostasis-20in-20the-20aged-20skeletal-20muscle.-20The-20glutathione-20redox-20status-20was-20more-20reduced-20and-20thiol-20redox-20proteomics-20indicated-20a-20robust-20reversal-20of-20cysteine-20S-2Dglutathionylation-20post-2Dtranslational-20modifications-20across-20the-20skeletal-20muscle-20proteome.-20The-20gastrocnemius-20in-20the-20age+SS-2D31-20mice-20was-20more-20fatigue-20resistant-20with-20significantly-20greater-20mass-20compared-20to-20aged-20controls.-20This-20contributed-20to-20a-20significant-20increase-20in-20treadmill-20endurance-20compared-20to-20both-20pretreatment-20and-20untreated-20control-20values.-20These-20results-20demonstrate-20that-20the-20shift-20of-20redox-20homeostasis-20due-20to-20mitochondrial-20oxidant-20production-20in-20aged-20muscle-20is-20a-20key-20factor-20in-20energetic-20defects-20and-20exercise-20intolerance.-20Treatment-20with-20SS-2D31-20restores-20redox-20homeostasis,-20improves-20mitochondrial-20quality,-20and-20increases-20exercise-20tolerance-20without-20an-20increase-20in-20mitochondrial-20content.-20Since-20elamipretide-20is-20currently-20in-20clinical-20trials-20these-20results-20indicate-20it-20may-20have-20direct-20translational-20value-20for-20improving-20exercise-20tolerance-20and-20quality-20of-20life-20in-20the-20elderly." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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