Search by property

Property "Has-20abstract" (as page type) with input value "Preeclampsia-20(PE)-20is-20a-20complicated-20obstetric-20complication-20characterized-20by-20increased-20blood-20pressure,-20decreased-20trophoblast-20invasion,-20and-20inflammation.-20The-20growth-20arrest-2Dspecific-206-20(Gas6)-20protein-20is-20known-20to-20induce-20dynamic-20cellular-20responses-20and-20is-20elevated-20in-20PE.-20Gas6-20binds-20to-20the-20AXL-20tyrosine-20kinase-20receptor-20and-20AXL-2Dmediated-20signaling-20is-20implicated-20in-20proliferation-20and-20migration-20observed-20in-20several-20tissues.-20Our-20laboratory-20utilized-20Gas6-20to-20induce-20preeclamptic-2Dlike-20conditions-20in-20pregnant-20rats.-20Our-20objective-20was-20to-20determine-20the-20role-20of-20Gas6-2FAXL-20signaling-20as-20a-20possible-20model-20of-20PE.-20Briefly,-20pregnant-20rats-20were-20spanided-20into-203-20groups-20that-20received-20daily-20intraperitoneal-20injections-20(from-20gestational-20day-207.5-2D17.5)-20of-20PBS,-20Gas6,-20or-20Gas6-20+-20R428-20(an-20AXL-20inhibitor-20administered-20from-20gestational-20day-2013.5-2D17.5).-20Animals-20dispensed-20Gas6-20experienced-20elevated-20blood-20pressure,-20increased-20proteinuria,-20augmented-20caspase-2D3-20mediated-20placental-20apoptosis-20and-20diminished-20trophoblast-20invasion.-20Gas6-20also-20enhanced-20expression-20of-20several-20PE-20related-20genes-20and-20a-20number-20of-20inflammatory-20mediators.-20Gas6-20further-20enhanced-20placental-20oxidative-20stress-20and-20impaired-20mitochondrial-20respiration.-20Each-20of-20these-20PE-20related-20characteristics-20were-20ameliorated-20in-20dams-20and-2For-20their-20placentae-20when-20AXL-20inhibition-20by-20R428-20occurred-20in-20tandem-20with-20Gas6-20treatment.-20We-20conclude-20that-20Gas6-20signaling-20is-20capable-20of-20inducing-20PE-20and-20that-20inhibition-20of-20AXL-20prevents-20disease-20progression-20in-20pregnant-20rats.-20These-20results-20provide-20insight-20into-20pathways-20associated-20with-20PE-20that-20could-20be-20useful-20in-20the-20clarification-20of-20potential-20therapeutic-20approaches.-0A-0A-3Csmall-3E©-20The-20Author(s)-202019.-20Published-20by-20Oxford-20University-20Press-20on-20behalf-20of-20Society-20for-20the-20Study-20of-20Reproduction.-3C-2Fsmall-3E" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)