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Property "Has-20abstract" (as page type) with input value "OBJECTIVE:-20To-20examine-20the-20association-20of-20gene-20variants-20of-20uncoupling-20proteins-20(UCP)-2D2-20and-20-2D3-20with-20obesity-20and-20gastrointestinal-20(GI)-20traits.-0A-0AMETHODS:-20In-20255-20overweight-20or-20obese-20adults,-20the-20associations-20of-20gene-20variants-20in-20UCP-2D2-20(-2D3474,-20rs659366)-20and-20UCP-2D3-20(rs1626521,-20rs2075577,-20rs15763)-20with-20body-20weight-20(BW)-20and-20GI-20traits-20were-20studied.-20Gene-20variants-20were-20genotyped-20by-20TaqMan®-20assay.-20The-20associations-20of-20genotypes-20with-20BW-20and-20GI-20traits-20(gastric-20emptying,-20gastric-20volume,-20satiety-20by-20buffet-20meal,-20satiation-20by-20nutrient-20drink-20test-20and-20GI-20hormones)-20were-20assessed-20using-20ANOVA-20corrected-20for-20false-20detection-20rate-20(FDR).-0A-0ARESULTS:-20A-20novel-20UCP-2D3-20gene-20variant,-20rs1626521,-20was-20identified-3B-20it-20was-20associated-20with-20BW-20(-27-27P-27-27 = 0.039),-20waist-20circumference-20(-27-27P-27-27 = 0.035),-20and-20significantly-20higher-20postprandial-20gastric-20volume-20(-27-27P-27-27 = 0.003)-20and-20calories-20ingested-20at-20buffet-20meal-20(-27-27P-27-27 = 0.006,-20both-20significant-20with-20FDR).-20In-20a-20subgroup-20of-2011-20participants,-20rs1626521-20was-20also-20associated-20with-20reduced-20mitochondrial-20bioenergetics-20efficiency-20in-20skeletal-20muscle-20(-27-27P-27-27 = 0.051).-20In-20an-20-27-27in-20vitro-27-27-20study-20in-20HEK293-20cells,-20rs1626521-20reduced-20UCP-2D3-20protein-20expression-20(-27-27P-27-27 = 0.049).-20Associations-20detected-20between-20other-20genotypes-20and-20GI-20traits-20were-20nonsignificant-20with-20FDR.-0A-0ACONCLUSIONS:-20A-20newly-20identified-20functional-20variant-20(rs1626521)-20in-20UCP-2D3-20affects-20postprandial-20gastric-20functions-20and-20satiety-20and-20may-20contribute-20to-20weight-20gain-20and-20alter-20human-20mitochondrial-20function." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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