Search by property

Property "Has-20abstract" (as page type) with input value "Naked-20mole-2Drats-20(NMRs)-20are-20mouse-2Dsized-20mammals-20that-20exhibit-20an-20exceptionally-20long-20lifespan-20(-3E30-20vs.-20-3C4-20years-20for-20mice),-20and-20resist-20aging-2Drelated-20pathologies-20such-20as-20cardiovascular-20and-20pulmonary-20diseases,-20cancer,-20and-20neurodegeneration.-20However,-20the-20mechanisms-20underlying-20this-20exceptional-20longevity-20and-20disease-20resistance-20remain-20poorly-20understood.-20The-20oxidative-20stress-20theory-20of-20aging-20posits-20that-20(a)-20senescence-20results-20from-20the-20accumulation-20of-20oxidative-20damage-20inflicted-20by-20reactive-20oxygen-20species-20(ROS)-20of-20mitochondrial-20origin,-20and-20(b)-20mitochondria-20of-20long-2Dlived-20species-20produce-20less-20ROS-20than-20do-20mitochondria-20of-20short-2Dlived-20species.-20However,-20comparative-20studies-20over-20the-20past-2028-20years-20have-20produced-20equivocal-20results-20supporting-20this-20latter-20prediction.-20We-20hypothesized-20that,-20rather-20than-20differences-20in-20ROS-20generation,-20the-20capacity-20of-20mitochondria-20to-20consume-20ROS-20might-20distinguish-20long-2Dlived-20species-20from-20short-2Dlived-20species.-20To-20test-20this-20hypothesis,-20we-20compared-20mitochondrial-20production-20and-20consumption-20of-20hydrogen-20peroxide-20(H-3Csub-3E2-3C-2Fsub-3EO-3Csub-3E2-3C-2Fsub-3E-3B-20as-20a-20proxy-20of-20overall-20ROS-20metabolism)-20between-20NMR-20and-20mouse-20skeletal-20muscle-20and-20heart.-20We-20found-20that-20the-20two-20species-20had-20comparable-20rates-20of-20mitochondrial-20H-3Csub-3E2-3C-2Fsub-3EO-3Csub-3E2-3C-2Fsub-3E-20generation-20in-20both-20tissues-3B-20however,-20the-20capacity-20of-20mitochondria-20to-20consume-20ROS-20was-20markedly-20greater-20in-20NMRs.-20Specifically,-20maximal-20observed-20consumption-20rates-20were-20approximately-20two-20and-20fivefold-20greater-20in-20NMRs-20than-20in-20mice,-20for-20skeletal-20muscle-20and-20heart,-20respectively.-20Our-20results-20indicate-20that-20differences-20in-20matrix-20ROS-20detoxification-20capacity-20between-20species-20may-20contribute-20to-20their-20spanergence-20in-20lifespan.-0A-0A-3Csmall-3E©-202019-20The-20Authors.-20Aging-20Cell-20published-20by-20the-20Anatomical-20Society-20and-20John-20Wiley-20-26-20Sons-20Ltd.-3C-2Fsmall-3E" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)