Search by property

This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

Search by property

Property "Has-20abstract" (as page type) with input value "Mitochondria-20play-20an-20important-20role-20in-20cell-20life-20and-20in-20the-20regulation-20of-20cell-20death.-20In-20addition,-20mitochondrial-20dysfunction-20contributes-20to-20a-20wide-20range-20of-20neuropathologies.-20The-20nucleoside-20Guanosine-20(GUO)-20is-20an-20endogenous-20molecule,-20presenting-20antioxidant-20properties,-20possibly-20due-20to-20its-20direct-20scavenging-20ability-20and-2For-20from-20its-20capacity-20to-20activate-20the-20antioxidant-20defense-20system.-20GUO-20demonstrate-20a-20neuroprotective-20effect-20due-20to-20the-20modulation-20of-20the-20glutamatergic-20system-20and-20maintenance-20of-20the-20redox-20system.-20Thus,-20considering-20the-20few-20studies-20focused-20on-20the-20direct-20effects-20of-20GUO-20on-20mitochondrial-20bioenergetics,-20we-20designed-20a-20study-20to-20evaluate-20the-20-27-27in-20vitro-27-27-20effects-20of-20GUO-20on-20rat-20mitochondrial-20function,-20as-20well-20as-20against-20Ca-3Csup-3E2+-3C-2Fsup-3E-2Dinduced-20impairment.-20Our-20results-20indicate-20that-20GUO-20prevented-20mitochondrial-20dysfunction-20induced-20by-20Ca-3Csup-3E2+-3C-2Fsup-3E-20misbalance,-20once-20GUO-20was-20able-20to-20reduce-20mitochondrial-20swelling-20in-20the-20presence-20of-20Ca-3Csup-3E2+-3C-2Fsup-3E,-20as-20well-20as-20ROS-20production-20and-20hydrogen-20peroxide-20levels,-20and-20to-20increase-20manganese-20superoxide-20dismutase-20activity,-20oxidative-20phosphorylation-20and-20tricarboxylic-20acid-20cycle-20activities.-20Our-20study-20indicates-20for-20the-20first-20time-20that-20GUO-20could-20direct-20prevent-20the-20mitochondrial-20damage-20induced-20by-20Ca-3Csup-3E2+-3C-2Fsup-3E-20and-20that-20these-20effects-20were-20not-20related-20to-20its-20scavenging-20properties.-20Our-20data-20indicates-20that-20GUO-20could-20be-20included-20as-20a-20new-20pharmacological-20strategy-20for-20diseases-20linked-20to-20mitochondrial-20dysfunction." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)

Property: Value:

List of results

No results.