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Property "Has-20abstract" (as page type) with input value "Metformin-20has-20been-20extensively-20studied-20for-20its-20impact-20on-20cancer-20cell-20metabolism-20and-20anticancer-20potential.-20Despite-20evidence-20of-20significant-20reduction-20in-20cancer-20occurrence-20in-20diabetic-20patients-20taking-20metformin,-20phase-20II-20cancer-20trials-20of-20the-20agent-20have-20been-20disappointing,-20quite-20possibly-20because-20of-20the-20lack-20of-20molecular-20mechanism-2Dbased-20patient-20stratification.-20In-20an-20effort-20to-20identify-20cancers-20that-20are-20responsive-20to-20metformin,-20we-20discovered-20that-20mitochondria-20respiratory-20capacity-20and-20respiratory-20reserve,-20which-20vary-20widely-20among-20cancer-20cells,-20correlate-20strongly-20to-20metformin-20sensitivity-20in-20both-20the-20-27-27in-20vitro-27-27-20and-20-27-27in-20vivo-27-27-20settings.-20A-20causal-20relationship-20between-20respiratory-20function-20and-20metformin-20sensitivity-20is-20demonstrated-20in-20studies-20in-20which-20we-20lowered-20respiratory-20capacity-20by-20either-20genetic-20knockdown-20or-20pharmacologic-20suppression-20of-20electron-20transport-20chain-20components,-20rendering-20cancer-20cells-20more-20vulnerable-20to-20metformin.-20These-20findings-20led-20us-20to-20predict,-20and-20experimentally-20validate,-20that-20metformin-20and-20AMP-20kinase-20inhibition-20synergistically-20suppress-20cancer-20cell-20proliferation.-0A-0A-3Csmall-3E©2019-20American-20Association-20for-20Cancer-20Research.-3C-2Fsmall-3E" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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