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Property "Has-20abstract" (as page type) with input value "Lafora-20disease-20(LD)-20is-20a-20fatal-20form-20of-20progressive-20myoclonus-20epilepsy-20characterized-20by-20the-20accumulation-20of-20insoluble-20poorly-20branched-20glycogen-2Dlike-20inclusions-20named-20Lafora-20bodies-20(LBs)-20in-20the-20brain-20and-20peripheral-20tissues.-20In-20the-20brain,-20since-20its-20first-20discovery-20in-201911,-20it-20was-20assumed-20that-20these-20glycogen-20inclusions-20were-20only-20present-20in-20affected-20neurons.-20Mouse-20models-20of-20LD-20have-20been-20obtained-20recently,-20and-20we-20and-20others-20have-20been-20able-20to-20report-20the-20accumulation-20of-20glycogen-20inclusions-20in-20the-20brain-20of-20LD-20animals,-20what-20recapitulates-20the-20hallmark-20of-20the-20disease.-20In-20this-20work-20we-20present-20evidence-20indicating-20that,-20although-20in-20mouse-20models-20of-20LD-20glycogen-20inclusions-20co-2Dlocalize-20with-20neurons,-20as-20originally-20established,-20most-20of-20them-20co-2Dlocalize-20with-20astrocytic-20markers-20such-20as-20glial-20fibrillary-20acidic-20protein-20(GFAP)-20and-20glutamine-20synthase.-20In-20addition,-20we-20have-20observed-20that-20primary-20cultures-20of-20astrocytes-20from-20LD-20mouse-20models-20accumulate-20higher-20levels-20of-20glycogen-20than-20controls.-20These-20results-20suggest-20that-20astrocytes-20may-20play-20a-20crucial-20role-20in-20the-20pathophysiology-20of-20Lafora-20disease,-20as-20the-20accumulation-20of-20glycogen-20inclusions-20in-20these-20cells-20may-20affect-20their-20regular-20functionality-20leading-20then-20to-20a-20possible-20neuronal-20dysfunction." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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