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Property "Has-20abstract" (as page type) with input value "Exposure-20to-20maternal-20over-2Dnutrition-20-27-27in-20utero-27-27-20is-20linked-20with-20developmental-20programming-20of-20obesity,-20metabolic-20syndrome-20and-20cardiovascular-20disease-20in-20offspring,-20which-20may-20be-20exacerbated-20by-20postnatal-20high-2Dfat-20(HF)-20diet.-20Skeletal-20muscle-20mitochondrial-20function-20contributes-20to-20substrate-20metabolism-20and-20is-20impaired-20in-20metabolic-20disease.-20We-20examined-20muscle-20mitochondrial-20respiration-20in-20male-20and-20female-20mice-20exposed-20to-20maternal-20HF-20diet-20-27-27in-20utero-27-27,-20followed-20by-20postweaning-20HF-20diet-20until-20middle-20age.-20After-20-27-27in-20utero-27-27-20exposure-20to-20maternal-20control-20(Con)-20or-20HF-20diet-20(45-25-20kcal-20fat-3B-2039.4-25-20lard,-205.5-25-20soybean-20oil),-20offspring-20were-20weaned-20to-20Con-20or-20HF,-20creating-20four-20groups:-20Con-2FCon-20(male-2Ffemale-20(m-2Ff),-20n=8-2F8),-20Con-2FHF-20(m-2Ff,-20n=7-2F4),-20HF-2FCon-20(m-2Ff,-20n=9-2F6)-20and-20HF-2FHF-20(m-2Ff,-20n=4-2F4).-20Oxidative-20phosphorylation-20(OXPHOS)-20and-20electron-20transfer-20system-20(ETS)-20capacity-20were-20measured-20in-20permeabilized-20gastrocnemius-20bundles.-20Maternal-20HF-20diet-20increased-20fasting-20glucose-20and-20lean-20body-20mass-20in-20males-20and-20body-20fat-20percentage-20in-20both-20sexes-20(P⩽0.05).-20Maximal-20adenosine-20diphosphate-2Dstimulated-20respiration-20(complex-20I-20OXPHOS)-20was-20decreased-20by-20maternal-20HF-20diet-20in-20female-20offspring-20(-2D21-25,-20P=0.053),-20but-20not-20in-20male-20(-2D0-25,-20P-3E0.05).-20Sexually-20spanergent-20responses-20were-20exacerbated-20in-20offspring-20weaned-20to-20HF-20diet.-20In-20females,-20OXPHOS-20capacity-20was-20lower-20(-2D28-25,-20P=0.041)-20when-20weaned-20to-20high-2Dfat-20(HF-2FHF)-20v.-20control-20diet-20(HF-2FCon).-20In-20males,-20OXPHOS-20(+33-25,-20P=0.009)-20and-20ETS-20(+42-25,-20P=0.016)-20capacity-20increased.-20Our-20data-20suggest-20that-20maternal-20lard-2Dbased-20HF-20diet,-20rich-20in-20saturated-20fat,-20affects-20offspring-20skeletal-20muscle-20respiration-20in-20a-20sex-2Ddependent-20manner,-20and-20these-20differences-20are-20exacerbated-20by-20HF-20diet-20in-20adulthood." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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