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Property "Has-20abstract" (as page type) with input value "Communication-20between-20the-20endoplasmic-20reticulum-20(ER)-20and-20mitochondria-20plays-20a-20pivotal-20role-20in-20Ca-3Csup-3E2+-3C-2Fsup-3E-20signaling,-20energy-20metabolism,-20and-20cell-20survival.-20Dysfunction-20in-20this-20cross-2Dtalk-20leads-20to-20metabolic-20and-20neurodegenerative-20diseases.-20Wolfram-20syndrome-20is-20a-20fatal-20neurodegenerative-20disease-20caused-20by-20mutations-20in-20the-20ER-2Dresident-20protein-20WFS1.-20Here,-20we-20showed-20that-20WFS1-20formed-20a-20complex-20with-20neuronal-20calcium-20sensor-201-20(NCS1)-20and-20inositol-201,4,5-2Dtrisphosphate-20receptor-20(IP-3Csub-3E3-3C-2Fsub-3ER)-20to-20promote-20Ca-3Csup-3E2+-3C-2Fsup-3E-20transfer-20between-20the-20ER-20and-20mitochondria.-20In-20addition,-20we-20found-20that-20NCS1-20abundance-20was-20reduced-20in-20WFS1-2Dnull-20patient-20fibroblasts,-20which-20showed-20reduced-20ER-2Dmitochondria-20interactions-20and-20Ca-3Csup-3E2+-3C-2Fsup-3E-20exchange.-20Moreover,-20in-20WFS1-2Ddeficient-20cells,-20NCS1-20overexpression-20not-20only-20restored-20ER-2Dmitochondria-20interactions-20and-20Ca-3Csup-3E2+-3C-2Fsup-3E-20transfer-20but-20also-20rescued-20mitochondrial-20dysfunction.-20Our-20results-20describe-20a-20key-20role-20of-20NCS1-20in-20ER-2Dmitochondria-20cross-2Dtalk,-20uncover-20a-20pathogenic-20mechanism-20for-20Wolfram-20syndrome,-20and-20potentially-20reveal-20insights-20into-20the-20pathogenesis-20of-20other-20neurodegenerative-20diseases." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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