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Property "Has-20abstract" (as page type) with input value "Colorectal-20cancer-20(CRC)-20is-20associated-20with-20metabolic-20and-20redox-20perturbation.-20The-20mitochondrial-20transporter-20uncoupling-20protein-202-20(UCP2)-20controls-20cell-20proliferation-20-27-27in-20vitro-27-27-20through-20the-20modulation-20of-20cellular-20metabolism,-20but-20the-20underlying-20mechanism-20in-20tumors-20-27-27in-20vivo-27-27-20remains-20unexplored.-20Using-20murine-20intestinal-20cancer-20models-20and-20CRC-20patient-20samples,-20we-20find-20higher-20UCP2-20protein-20levels-20in-20tumors-20compared-20to-20their-20non-2Dtumoral-20counterparts.-20We-20reveal-20the-20tumor-2Dsuppressive-20role-20of-20UCP2-20as-20its-20deletion-20enhances-20colon-20and-20small-20intestinal-20tumorigenesis-20in-20AOM-2FDSS-2Dtreated-20and-20Apc-3Csup-3EMin-2F+-3C-2Fsup-3E-20mice,-20respectively,-20and-20correlates-20with-20poor-20survival-20in-20the-20latter-20model.-20Mechanistically,-20UCP2-20loss-20increases-20levels-20of-20oxidized-20glutathione-20and-20proteins-20in-20tumors.-20UCP2-20deficiency-20alters-20glycolytic-20pathways-20while-20promoting-20phospholipid-20synthesis,-20thereby-20limiting-20the-20availability-20of-20NADPH-20for-20buffering-20oxidative-20stress.-20We-20show-20that-20UCP2-20loss-20renders-20colon-20cells-20more-20prone-20to-20malignant-20transformation-20through-20metabolic-20reprogramming-20and-20perturbation-20of-20redox-20homeostasis-20and-20could-20favor-20worse-20outcomes-20in-20CRC.-0A-0A-3Csmall-3ECopyright-20©-202019-20The-20Authors.-20Published-20by-20Elsevier-20Inc.-20All-20rights-20reserved.-3C-2Fsmall-3E" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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