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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Cardiolipin-20(CL)-20is-20a-20phospholipid-20at-20the-20heart-20of-20mitochondrial-20metabolism,-20which-20plays-20a-20key-20role-20in-20mitochondrial-20function-20and-20bioenergetics.-20Among-20mitochondrial-20activity-20regulators,-20SIRT3-20plays-20a-20crucial-20role-20in-20controlling-20the-20acetylation-20status-20of-20many-20enzymes-20participating-20in-20the-20energy-20metabolism-20in-20particular-20concerning-20lipid-20metabolism-20and-20fatty-20acid-20oxidation.-20Data-20suggest-20that-20possible-20connection-20may-20exist-20between-20SIRT3-20and-20CL-20status-20that-20has-20not-20been-20evaluated-20in-20skeletal-20muscle.-20In-20the-20present-20study,-20we-20have-20characterized-20skeletal-20muscle-20lipids-20as-20well-20as-20mitochondrial-20lipids-20composition-20in-20mice-20overexpressing-20long-20(SIRT3-2DM1)-20and-20short-20(SIRT3-2DM3)-20isoforms-20of-20SIRT3.-20Particular-20attention-20has-20been-20paid-20for-20CL.-20We-20reported-20no-20alteration-20in-20muscle-20lipids-20content-20and-20fatty-20acids-20composition-20between-20the-20two-20mice-20SIRT3-20strains-20and-20the-20control-20mice.-20However,-20mitochondrial-20CL-20content-20was-20significantly-20decreased-20in-20SIRT3-2DM3-20mice-20and-20associated-20to-20an-20upregulation-20of-20tafazzin-20gene-20expression.-20In-20addition,-20mitochondrial-20phospholipids-20and-20fatty-20acids-20composition-20was-20altered-20with-20an-20increase-20in-20the-20PC-2FPE-20ratio-20and-20arachidonic-20acid-20content-20and-20a-20reduction-20in-20the-20MUFA-2FSFA-20ratio.-20These-20modifications-20in-20mitochondrial-20membrane-20composition-20are-20associated-20with-20a-20reduction-20in-20the-20enzymatic-20activities-20of-20mitochondrial-20respiratory-20chain-20complexes-20I-20and-20IV.-20In-20spite-20of-20these-20mitochondrial-20enzymatic-20alterations,-20skeletal-20muscle-20mitochondrial-20respiration-20remained-20similar-20in-20SIRT3-2DM3-20and-20control-20mice.-20Surprisingly,-20none-20of-20those-20metabolic-20alterations-20were-20detected-20in-20mitochondria-20from-20SIRT3-2DM1-20mice.-20In-20conclusion,-20our-20data-20indicate-20a-20specific-20action-20of-20the-20shorter-20SIRT3-20isoform-20on-20lipid-20mitochondrial-20membrane-20biosynthesis-20and-20functioning." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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