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Property "Has-20abstract" (as page type) with input value "Blood-20is-20a-20fluid-20connective-20tissue-20of-20human-20body,-20where-20it-20plays-20vital-20functions-20for-20the-20nutrition,-20defense-20and-20well-2Dbeing-20of-20the-20organism.-20When-20circulating-20in-20peripheral-20districts,-20it-20is-20exposed-20to-20some-20physical-20stresses-20coming-20from-20outside-20the-20human-20body,-20as-20electromagnetic-20fields-20(EMFs)-20which-20can-20cross-20the-20skin.-20Such-20fields-20may-20interact-20with-20biomolecules-20possibly-20inducing-20non-20thermal-2Dmediated-20biological-20effects-20at-20the-20cellular-20level.-20In-20this-20study,-20the-20occurrence-20of-20biochemical-2Fbiological-20modifications-20in-20human-20peripheral-20blood-20lympho-2Dmonocytes-20exposed-20in-20a-20reverberation-20chamber-20for-20times-20ranging-20from-201-20to-2020-20h-20to-20EMFs-20at-201.8-20GHz-20frequency-20and-20200-20V-2Fm-20electric-20field-20strength-20was-20investigated.-20Morphological-20analysis-20of-20adherent-20cells-20unveiled,-20in-20some-20of-20these,-20appearance-20of-20an-20enlarged-20and-20deformed-20shape-20after-20EMFs-20exposure.-20Raman-20spectra-20of-20the-20nuclear-20compartment-20of-20cells-20exposed-20to-20EMFs-20revealed-20the-20onset-20of-20biochemical-20modifications,-20mainly-20consisting-20in-20the-20reduction-20of-20the-20DNA-20backbone-2Dlinked-20vibrational-20modes.-20Respirometric-20measurements-20of-20mitochondrial-20activity-20in-20intact-20lympho-2Dmonocytes-20resulted-20in-20increase-20of-20the-20resting-20oxygen-20consumption-20rate-20after-2020-20h-20of-20exposure,-20which-20was-20coupled-20to-20a-20significant-20increase-20of-20the-20FoF1-2DATP-20synthase-2Drelated-20oxygen-20consumption.-20Notably,-20at-20lower-20time-2Dintervals-20of-20EMFs-20exposure-20(i.e.-205-20and-2012-20h)-20a-20large-20increase-20of-20the-20proton-20leak-2Drelated-20respiration-20was-20observed-20which,-20however,-20recovered-20at-20control-20levels-20after-2020-20h-20exposure.-20Confocal-20microscopy-20analysis-20of-20the-20mitochondrial-20membrane-20potential-20supported-20the-20respiratory-20activities-20whereas-20no-20significant-20variations-20in-20the-20mitochondrial-20mass-2Fmorphology-20was-20observed-20in-20EMFs-2Dexposed-20lympho-2Dmonocytes.-20Finally,-20altered-20redox-20homeostasis-20was-20shown-20in-20EMFs-2Dexposed-20lympho-2Dmonocytes,-20which-20progressed-20differently-20in-20nucleated-20cellular-20subsets.-20These-20results-20suggest-20the-20occurrence-20of-20adaptive-20mechanisms-20put-20in-20action,-20likely-20via-20redox-20signaling,-20to-20compensate-20for-20early-20impairments-20of-20the-20oxidative-20phosphorylation-20system-20caused-20by-20exposure-20to-20EMFs.-20Overall-20the-20data-20presented-20warn-20for-20health-20safety-20of-20people-20involved-20in-20long-2Dterm-20exposure-20to-20electromagnetic-20fields,-20although-20further-20studies-20are-20required-20to-20pinpoint-20the-20leukocyte-20cellular-20subset(s)-20selectively-20targeted-20by-20the-20EMFs-20action-20and-20the-20mechanisms-20by-20which-20it-20is-20achieved." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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