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Property "Has-20abstract" (as page type) with input value "BK-3Csub-3ECa-3C-2Fsub-3E-20channels,-20originally-20discovered-20in-20-27-27Drosophila-20melanogaster-27-27-20as-20slowpoke-20(slo),-20are-20recognized-20for-20their-20roles-20in-20cellular-20and-20organ-20physiology.-20Pharmacological-20approaches-20implicated-20BK-3Csub-3ECa-3C-2Fsub-3E-20channels-20in-20cellular-20and-20organ-20protection-20possibly-20for-20their-20ability-20to-20modulate-20mitochondrial-20function.-20However,-20the-20direct-20role-20of-20BK-3Csub-3ECa-3C-2Fsub-3E-20channels-20in-20regulating-20mitochondrial-20structure-20and-20function-20is-20not-20deciphered.-20Here,-20we-20demonstrate-20that-20BK-3Csub-3ECa-3C-2Fsub-3E-20channels-20are-20present-20in-20fly-20mitochondria,-20and-20slo-20mutants-20show-20structural-20and-20functional-20defects-20in-20mitochondria.-20slo-20mutants-20display-20an-20increase-20in-20reactive-20oxygen-20species-20and-20the-20modulation-20of-20ROS-20affected-20their-20survival.-20We-20also-20found-20that-20the-20absence-20of-20BK-3Csub-3ECa-3C-2Fsub-3E-20channels-20reduced-20the-20lifespan-20of-20-27-27Drosophila-27-27,-20and-20overexpression-20of-20human-20BK-3Csub-3ECa-3C-2Fsub-3E-20channels-20in-20flies-20extends-20life-20span-20in-20males.-20Our-20study-20establishes-20the-20presence-20of-20BK-3Csub-3ECa-3C-2Fsub-3E-20channels-20in-20mitochondria-20of-20-27-27Drosophila-27-27-20and-20ascertains-20its-20novel-20physiological-20role-20in-20regulating-20mitochondrial-20structural-20and-20functional-20integrity,-20and-20lifespan." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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