Difference between revisions of "Scaini 2015 Abstract IOC106"
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pathophysiology of BD and that omega-3 (ω3) fatty acids have beneficial | pathophysiology of BD and that omega-3 (ω3) fatty acids have beneficial | ||
properties in the central nervous system, by modulate energy metabolism. | properties in the central nervous system, by modulate energy metabolism. | ||
Thus, in the present | Thus, in the present study we evaluate the effect of ω3 fatty acids alone or in | ||
combination with lithium or valproate on bioenergetic parameters, namely | combination with lithium or valproate on bioenergetic parameters, namely | ||
respiratory complexes (CI, CII, CII–III, CIV), malate dehydrogenase, succinate | respiratory complexes (CI, CII, CII–III, CIV), malate dehydrogenase, succinate | ||
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succinate dehydrogenase, complexes II and IV activities. However, the | succinate dehydrogenase, complexes II and IV activities. However, the | ||
decrease in CK activity was reversed only with ω3 fatty acids in association | decrease in CK activity was reversed only with ω3 fatty acids in association | ||
with VPA. The present findings support the idea that ω3 fatty | with VPA. The present findings support the idea that ω3 fatty acid plays an | ||
important role in the modulation of energy metabolism, and exercise essential | important role in the modulation of energy metabolism, and exercise essential | ||
antioxidant capacity in the central nervous system, suggesting that the ω3 | antioxidant capacity in the central nervous system, suggesting that the ω3 | ||
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{{Labeling | {{Labeling | ||
|area=Pharmacology;toxicology | |||
|organism=Rat | |organism=Rat | ||
|tissues=Nervous system | |||
|enzymes=Complex I, Complex II;succinate dehydrogenase, Complex IV;cytochrome c oxidase | |||
|additional=Labels | |additional=Labels | ||
}} | }} | ||
Revision as of 10:19, 2 October 2015
| Scaini G, Gomes LM, Carvalho-Silva M, Arent CO, Mariot E, Quevedo J, Streck EL (2015) Co-administration of omega-3 fatty acids and mood stabilizers reverses the impairment of bioenergetic parameters induced by fenproporex administration in hippocampus of rats. Mitochondr Physiol Network 20.10. |
Link:
Scaini G, Gomes LM, Carvalho-Silva M, Arent CO, Mariot E, Quevedo J, Streck EL (2015)
Event: IOC106 Schroecken
Bipolar disorder (BD) presents a complex alternating clinical course with recurrent mood changes including manic and depressive episodes. Moreover, studies show that changes in energy metabolism are involved in the pathophysiology of BD and that omega-3 (ω3) fatty acids have beneficial properties in the central nervous system, by modulate energy metabolism. Thus, in the present study we evaluate the effect of ω3 fatty acids alone or in combination with lithium or valproate on bioenergetic parameters, namely respiratory complexes (CI, CII, CII–III, CIV), malate dehydrogenase, succinate dehydrogenase, citrate synthase and creatine kinase activities. We observed a significant decrease of succinate dehydrogenase, complexes II and IV and creatine kinase activities in hippocampus of animals submitted to fenproporex administration, as compared to the control group. Additionally, the ω3 fatty acids in combination with VPA or Li were able to reverse the decrease in succinate dehydrogenase, complexes II and IV activities. However, the decrease in CK activity was reversed only with ω3 fatty acids in association with VPA. The present findings support the idea that ω3 fatty acid plays an important role in the modulation of energy metabolism, and exercise essential antioxidant capacity in the central nervous system, suggesting that the ω3 fatty acids may be a possible contributing in BD therapy.
Labels: MiParea: Pharmacology;toxicology
Organism: Rat
Tissue;cell: Nervous system
Enzyme: Complex I, Complex II;succinate dehydrogenase, Complex IV;cytochrome c oxidase
Labels
Affiliations and support
Center for Translational Psychiatry, Department of Psychiatry and Behavioral Sciences, UT Health Science Center at Houston, Houston, TX, USA;
Laboratory of Bioenergetics, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
