Difference between revisions of "Scaini 2015 Abstract IOC106"
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antioxidant capacity in the central nervous system, suggesting that the ω3 | antioxidant capacity in the central nervous system, suggesting that the ω3 | ||
fatty acids may be a possible contributing in BD therapy. | fatty acids may be a possible contributing in BD therapy. | ||
|mipnetlab=US TX Houston Quevedo J | |||
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|tissues=Nervous system | |tissues=Nervous system | ||
|enzymes=Complex I, Complex II;succinate dehydrogenase, Complex IV;cytochrome c oxidase | |enzymes=Complex I, Complex II;succinate dehydrogenase, Complex IV;cytochrome c oxidase | ||
}} | }} | ||
== Affiliations and support == | == Affiliations and support == | ||
1-Center Translational Psychiatry, Dept Psychiatry | |||
Center | Behavioral Sc, UT Health Sc Center Houston, TX, USA; 2-Lab Bioenergetics, Graduate Program Health Sc, Health Sc Unit, Univ Extremo Sul Catarinense, Criciúma, SC, Brazil; 3-Lab Neurosciences, Graduate Program in Health Sc, Health | ||
Behavioral | Sciences Unit, Univ Extremo Sul Catarinense, Criciúma, SC, Brazil. - [email protected] | ||
USA; | |||
Brazil | |||
Sciences Unit, | |||
Brazil | |||
Latest revision as of 15:15, 28 March 2018
| Scaini G, Gomes LM, Carvalho-Silva M, Arent CO, Mariot E, Quevedo J, Streck EL (2015) Co-administration of omega-3 fatty acids and mood stabilizers reverses the impairment of bioenergetic parameters induced by fenproporex administration in hippocampus of rats. Mitochondr Physiol Network 20.10. |
Link:
Scaini G, Gomes LM, Carvalho-Silva M, Arent CO, Mariot E, Quevedo J, Streck EL (2015)
Event: IOC106 Schroecken
Bipolar disorder (BD) presents a complex alternating clinical course with recurrent mood changes including manic and depressive episodes. Moreover, studies show that changes in energy metabolism are involved in the pathophysiology of BD and that omega-3 (ω3) fatty acids have beneficial properties in the central nervous system, by modulate energy metabolism. Thus, in the present study we evaluate the effect of ω3 fatty acids alone or in combination with lithium or valproate on bioenergetic parameters, namely respiratory complexes (CI, CII, CII–III, CIV), malate dehydrogenase, succinate dehydrogenase, citrate synthase and creatine kinase activities. We observed a significant decrease of succinate dehydrogenase, complexes II and IV and creatine kinase activities in hippocampus of animals submitted to fenproporex administration, as compared to the control group. Additionally, the ω3 fatty acids in combination with VPA or Li were able to reverse the decrease in succinate dehydrogenase, complexes II and IV activities. However, the decrease in CK activity was reversed only with ω3 fatty acids in association with VPA. The present findings support the idea that ω3 fatty acid plays an important role in the modulation of energy metabolism, and exercise essential antioxidant capacity in the central nervous system, suggesting that the ω3 fatty acids may be a possible contributing in BD therapy.
• O2k-Network Lab: US TX Houston Quevedo J
Labels: MiParea: Pharmacology;toxicology
Organism: Rat
Tissue;cell: Nervous system
Enzyme: Complex I, Complex II;succinate dehydrogenase, Complex IV;cytochrome c oxidase
Affiliations and support
1-Center Translational Psychiatry, Dept Psychiatry Behavioral Sc, UT Health Sc Center Houston, TX, USA; 2-Lab Bioenergetics, Graduate Program Health Sc, Health Sc Unit, Univ Extremo Sul Catarinense, Criciúma, SC, Brazil; 3-Lab Neurosciences, Graduate Program in Health Sc, Health Sciences Unit, Univ Extremo Sul Catarinense, Criciúma, SC, Brazil. - [email protected]
