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Ravasz 2017 Neurochem Int - Revision history
2024-03-28T16:54:54Z
Revision history for this page on the wiki
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Radis Christina at 06:16, 28 March 2018
2018-03-28T06:16:39Z
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Radis Christina
https://wiki.oroboros.at/index.php?title=Ravasz_2017_Neurochem_Int&diff=146645&oldid=prev
Krumschnabel Gerhard at 08:31, 29 November 2017
2017-11-29T08:31:03Z
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Krumschnabel Gerhard
https://wiki.oroboros.at/index.php?title=Ravasz_2017_Neurochem_Int&diff=135461&oldid=prev
Kandolf Georg: Created page with "{{Publication |title=Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2017) Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GA..."
2017-05-16T13:51:21Z
<p>Created page with "{{Publication |title=Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2017) Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GA..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2017) Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochem Int [Epub ahead of print].<br />
|info=[https://www.ncbi.nlm.nih.gov/pubmed/28300620 PMID: 28300620]<br />
|authors=Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C<br />
|year=2017<br />
|journal=Neurochem Int<br />
|abstract=GABA is catabolized in the mitochondrial matrix through the GABA shunt, encompassing transamination to succinic semialdehyde followed by oxidation to succinate by the concerted actions of GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), respectively. Gamma-hydroxybutyrate (GHB) is a neurotransmitter and a psychoactive drug that could enter the citric acid cycle through transhydrogenation with α-ketoglutarate to succinic semialdehyde and d-hydroxyglutarate, a reaction catalyzed by hydroxyacid-oxoacid transhydrogenase (HOT). Here, we tested the hypothesis that the elevation in matrix succinate concentration caused by exogenous addition of GABA, succinic semialdehyde or GHB shifts the equilibrium of the reversible reaction catalyzed by succinate-CoA ligase towards ATP (or GTP) hydrolysis, effectively negating substrate-level phosphorylation (SLP). Mitochondrial SLP was addressed by interrogating the directionality of the adenine nucleotide translocase during anoxia in isolated mouse brain and liver mitochondria. GABA eliminated SLP, and this was rescued by the GABA-T inhibitors vigabatrin and aminooxyacetic acid. Succinic semialdehyde was an extremely efficient substrate energizing mitochondria during normoxia but mimicked GABA in abolishing SLP in anoxia, in a manner refractory to vigabatrin and aminooxyacetic acid. GHB could moderately energize liver but not brain mitochondria consistent with the scarcity of HOT expression in the latter. In line with these results, GHB abolished SLP in liver but not brain mitochondria during anoxia and this was unaffected by either vigabatrin or aminooxyacetic acid. It is concluded that when mitochondria catabolize GABA or succinic semialdehyde or GHB through the GABA shunt, their ability to perform SLP is impaired.<br />
<br />
Copyright © 2017 Elsevier Ltd. All rights reserved.<br />
|keywords=4-Aminobutyrate, Adenine nucleotide translocase, Aminooxyacetic acid, Anoxia, GHB, SSADH, Succinate, Vigabatrin<br />
|editor=[[Kandolf G]]<br />
|mipnetlab=HU Budapest Chinopoulos C<br />
}}<br />
{{Labeling<br />
|area=Respiration, Pharmacology;toxicology<br />
|organism=Mouse<br />
|tissues=Nervous system, Liver<br />
|preparations=Isolated mitochondria<br />
|couplingstates=OXPHOS<br />
|pathways=N, S, NS<br />
|instruments=Oxygraph-2k, O2k-Fluorometer<br />
|additional=Labels, 2017-05<br />
}}</div>
Kandolf Georg