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Pathway control ratio

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Revision as of 10:00, 28 February 2011 by Gnaiger Erich (talk | contribs)


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Pathway control ratio

Description

Substrate control ratios, SCR, are flux control ratios, FCR, at a constant mitochondrial coupling state. Whereas there are only three well-defined coupling states of mitochondrial respiration, L, P, E (LEAK, OXPHOS, ETS), numerous substrate states are possible.

Careful selection of the reference state, Jref, is required, for which some guidelines may be provided without the possibility to formulate general rules. FCR are best defined by taking Jref as the maximum flux (e.g. CI+IIE), such that flux in various other respiratory states, Ji, smaller or equal to Jref. However, this is not generally possible with SCR. For instance, the CI/CII substrate control ratio (at constant coupling state) may be larger or smaller than 1.0, depending on the mitochondrial source and various mitochondrial injuries. The CII-respiration may be selected preferentially as Jref, is mitochondria with variable CI-related injuries are studied.

Abbreviation: SCR

Reference: Gnaiger_2009_IJBCB; List of respiratory states


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Enzyme: Complex I, Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.  Regulation: Respiratory state"Respiratory state" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.