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Difference between revisions of "Pathway control ratio"

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{{MitoPedia
{{MitoPedia
|abbr=''SCR''
|abbr=''FCR''
|description='''Substrate control ratios''', ''SCR'', are [[flux control ratio]]s, ''FCR'', at a constant mitochondrial [[coupling control state]]. Whereas there are only three well-defined coupling control states of mitochondrial respiration, ''L'', ''P'', ''E'' ([[LEAK]], [[OXPHOS]], [[ET-pathway]]), numerous [[Electron transfer-pathway state]]s are possible. Β 
|description='''Substrate control ratios''' are [[flux control ratio]]s ''FCR'', at a constant mitochondrial [[coupling-control state]]. Whereas there are only three well-defined coupling-control states of mitochondrial respiration, ''L'', ''P'', ''E'' ([[LEAK respiration]], [[OXPHOS]], [[Electron transfer pathway]]), numerous [[Electron-transfer-pathway state]]s are possible. Β 


Careful selection of the reference state, ''J''<sub>ref</sub>, is required, for which some guidelines may be provided without the possibility to formulate general rules. ''FCR'' are best defined by taking ''J''<sub>ref</sub> as the maximum flux (e.g. [[NS |NS<sub>''E''</sub>]]), such that flux in various other respiratory states, ''J<sub>i</sub>'', is smaller or equal to ''J''<sub>ref</sub>. However, this is not generally possible with ''SCR''. For instance, the [[N/S substrate control ratio]] (at constant coupling control state) may be larger or smaller than 1.0, depending on the mitochondrial source and various mitochondrial injuries. The [[S-pathway control state]] may be selected preferentially as ''J''<sub>ref</sub>, if mitochondria with variable [[N]]-linked injuries are studied. In contrast, the [[reference state]], ''Z'', is strictly defined for [[flux control factor]]s.
Careful selection of the reference state, ''J''<sub>ref</sub>, is required, for which some guidelines may be provided without the possibility to formulate general rules. ''FCR'' are best defined by taking ''J''<sub>ref</sub> as the maximum flux (e.g. [[NS |NS<sub>''E''</sub>]]), such that flux in various other respiratory states, ''J<sub>i</sub>'', is smaller or equal to ''J''<sub>ref</sub>. However, this is not generally possible with ''FCR''. For instance, the [[N/S pathway control ratio]] (at constant coupling-control state) may be larger or smaller than 1.0, depending on the mitochondrial source and various mitochondrial injuries. The [[S-pathway control state]] may be selected preferentially as ''J''<sub>ref</sub>, if mitochondria with variable [[N]]-linked injuries are studied. In contrast, the [[reference state]], ''Z'', is strictly defined for [[flux control efficiency]].
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[MitoPedia: Respiratory states]]
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[MitoPedia: Respiratory states]]
}}
}}

Latest revision as of 11:20, 25 November 2020


high-resolution terminology - matching measurements at high-resolution


Pathway control ratio

Description

Substrate control ratios are flux control ratios FCR, at a constant mitochondrial coupling-control state. Whereas there are only three well-defined coupling-control states of mitochondrial respiration, L, P, E (LEAK respiration, OXPHOS, Electron transfer pathway), numerous Electron-transfer-pathway states are possible.

Careful selection of the reference state, Jref, is required, for which some guidelines may be provided without the possibility to formulate general rules. FCR are best defined by taking Jref as the maximum flux (e.g. NSE), such that flux in various other respiratory states, Ji, is smaller or equal to Jref. However, this is not generally possible with FCR. For instance, the N/S pathway control ratio (at constant coupling-control state) may be larger or smaller than 1.0, depending on the mitochondrial source and various mitochondrial injuries. The S-pathway control state may be selected preferentially as Jref, if mitochondria with variable N-linked injuries are studied. In contrast, the reference state, Z, is strictly defined for flux control efficiency.

Abbreviation: FCR

Reference: Gnaiger 2009 Int J Biochem Cell Biol, MitoPedia: Respiratory states


MitoPedia concepts: Respiratory control ratio 


MitoPedia methods: Respirometry