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Oxoglutarate dehydrogenase
Description
Oxoglutarate dehydrogenase (ฮฑ-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD+ to NADH and thus links to Complex I in the Electron transfer-pathway. OgDH is activated by low Ca2+ (<20 ยตM) but inactivated by high Ca2+ (>100 ยตM). OgDH is an important source of ROS.
Abbreviation: OgDH
Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci
MitoPedia topics: Enzyme
- The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
- The reaction catalyzed by OgDH is:
- Oxoglutarate (ฮฑ-ketoglutarate) + NAD+ + CoA โ Succinyl CoA + CO2 + NADH + H+
- The reaction catalyzed by OgDH is:
