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Oxoglutarate dehydrogenase

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Oxoglutarate dehydrogenase


Oxoglutarate dehydrogenase (α-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD+ to NADH and thus links to Complex I in the Electron transfer-pathway. OgDH is activated by low Ca2+ (<20 µM) but inactivated by high Ca2+ (>100 µM). OgDH is an important source of ROS.

Abbreviation: OgDH

Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci

MitoPedia topics: Enzyme 

The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
The reaction catalyzed by OgDH is:
Oxoglutarate (α-ketoglutarate) + NAD+ + CoA → Succinyl CoA + CO2 + NADH + H+