Oxoglutarate dehydrogenase

high-resolution terminology - matching measurements at high-resolution

Oxoglutarate dehydrogenase

Description

Oxoglutarate dehydrogenase (α-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD⁺ to NADH and thus links to Complex I in the Electron transfer-pathway. OgDH is activated by low Ca²⁺ (<20 µM) but inactivated by high Ca²⁺ (>100 µM). OgDH is an important source of ROS.

Abbreviation: OgDH

Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci

MitoPedia topics: Enzyme 

The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).

The reaction catalyzed by OgDH is:

Oxoglutarate (α-ketoglutarate) + NAD⁺ + CoA → Succinyl CoA + CO₂ + NADH + H⁺