Difference between revisions of "Oroboros Laboratory"
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The OROBOROS Mitochondrial Research Laboratory was opened during the course of the K-Regio project MitoCom Tyrol. Currently, the laboratory accommodates an Oncotyrol research project (project leader: A.Univ.Prof.Mag.Dr.Helmut Klocker) with focus on functional differences of mitochondria in human prostate tumor versus benign tissue. | The OROBOROS Mitochondrial Research Laboratory was opened during the course of the K-Regio project [[MitoCom| MitoCom Tyrol]]. Currently, the laboratory accommodates an [[Oncotyrol| Oncotyrol]] research project (project leader: A.Univ.Prof.Mag.Dr.Helmut Klocker) with focus on functional differences of mitochondria in human prostate tumor versus benign tissue. | ||
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* a phosphorylation control protocol in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions | * a phosphorylation control protocol in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions | ||
* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry| cell ergometry]]) | * various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry|cell ergometry]]) | ||
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[[OROBOROS_MitoLab:_visiting_scientists| Visiting scientists]] | [[OROBOROS_MitoLab:_visiting_scientists| Visiting scientists]] | ||
[[File:ORO Lab 1.jpg|250px]] [[File:ORO Lab 2.jpg|250px]] [[File:ORO Lab 3.jpg|250px]] [[File:ORO Lab 4.jpg|250px]] | |||
Revision as of 08:50, 16 April 2015
The OROBOROS MitoLab is a scientific research laboratory in Innsbruck, Austria, that is probably the world-wide best equipped lab for high-resolution respirometry. The OROBOROS MitoLab was started in June 2013 and comprises 140 sqm, which are divided into an office area and the state of the art research area with 24 O2k-Chambers (twelve Oxygraphs):
- Eight Oxygraph-2k instruments (16 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules are available for scientific research and routine biomedical applications
- Two O2k’s are used for specific testing
- Two O2k’s are devoted to instrumental development
For further information please click here: OROBOROS Support
The OROBOROS Mitochondrial Research Laboratory was opened during the course of the K-Regio project MitoCom Tyrol. Currently, the laboratory accommodates an Oncotyrol research project (project leader: A.Univ.Prof.Mag.Dr.Helmut Klocker) with focus on functional differences of mitochondria in human prostate tumor versus benign tissue.
OROBOROS INSTRUMENTS collaborates closely with research labs of the Medical University of Innsbruck. SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
- a phosphorylation control protocol in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions
- various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping (cell ergometry)
According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world.
