Difference between revisions of "Oroboros Laboratory"

Latest revision as of 16:58, 15 February 2024

Oroboros Laboratory

Mitochondria and Cell Research - the Oroboros Ecosystem

Scientists with a gentle touch of entrepreneurship

Oroboros O2k-Laboratory

42 O2k-Chambers (21 O2k)

The Oroboros O2k-Laboratory ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project MitoCom Tyrol in June 2013. It comprises 140 sqm which are divided into the office and research areas.

Twenty-one O2k instruments for HRR (42 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.

Two additional O2ks (4 chambers) are devoted to instrumental development.

According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.

» More details: Oroboros Support

Joint projects

Functional Mitochondrial Diagnostics (VASCage)	Rebecka Hardorp Alejandra Romero-Martinez, Dr. Joshua Wieser-Insole
ALAS	Ana Pfleger, Mag. Thomas Roach, PhD
TissueModels	Markus Keller, Dr. Anna Smaling, MRes
MitoKIN	Eduard Stefan, PhD Sophie Strich Omar Torres-Quesada, PhD
CureMILS	Marta Suarez-Cubero

OXPHOS analysis

SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using

coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping (cell ergometry).

» Current projects

» Partners in the Oroboros Ecosystem

» Visiting scientists

Keywords

Bioblast links: Oroboros Laboratory - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

» Oroboros Laboratory

» Projects

» Oroboros Laboratory: visiting scientists

» O2k-Open Support by Oroboros experts

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-The OROBOROS MitoLab is a scientific research laboratory in Innsbruck, Austria, that is probably the world-wide best equipped lab for high-resolution respirometry. The OROBOROS MitoLab was started in June 2013 and comprises 140 sqm, which are divided into an office area and the state of the art research area with 24 O2k-Chambers (twelve Oxygraphs):
+{{Template:OROBOROS header page name}}
+{{Template:OROBOROS Slogan}}
-* Eight Oxygraph-2k instruments (16 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules are available for scientific research and routine biomedical applications
+:::: <big>'''Scientists with a gentle touch of entrepreneurship'''</big>
+[[File:Lab in action.jpg|right|500px|Oroboros Laboratory]]
-* Two O2k’s are used for specific testing
-* Two O2k’s are devoted to instrumental development
+<!--[[File:OROBOROS MitoFit-Lab.jpg|left|240px |Oroboros O2k-Laboratory]]-->
-For further information please click here: [[OROBOROS Our service| OROBOROS Support]]
+__TOC__
+== Oroboros O2k-Laboratory ==
+:::: '''42 O2k-Chambers (21 O2k)'''
-The OROBOROS Mitochondrial Research Laboratory was opened during the course of the K-Regio project MitoCom Tyrol. Currently, the laboratory accommodates an Oncotyrol research project (project leader: A.Univ.Prof.Mag.Dr.Helmut Klocker) with focus on functional differences of mitochondria in human prostate tumor versus benign tissue.
+:::: The '''Oroboros O2k-Laboratory''' ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project [[MitoCom_O2k-Fluorometer| MitoCom Tyrol]] in June 2013. It comprises 140 sqm which are divided into the office and research areas.
+::::* Twenty-one O2k instruments for HRR (42 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.
+::::* Two additional O2ks (4 chambers) are devoted to instrumental development.
-OROBOROS INSTRUMENTS collaborates closely with research labs of the Medical University of Innsbruck. SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
+::::* According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.
-* a phosphorylation control protocol in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions
+::::» ''More details:'' [[O2k-technical_support_and_open_innovation|Oroboros Support]]
-* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry| cell ergometry]])
+=== Joint projects ===
+{| style="color: black;  width: 90%"
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[Functional Mitochondrial Diagnostics]]''' (VASCage)
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Hardorp Rebecka.jpg|'''[[Hardorp Rebecka|Rebecka Hardorp]]'''
+File:Romero Martinez Alejandra.jpeg|'''[[Romero Martinez Alejandra|Alejandra Romero-Martinez, Dr.]]'''
+File:Wieser-Insole J.jpg|'''[[Wieser-Insole Joshua|Joshua Wieser-Insole]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #ffffff" | '''[[ALAS]]'''
+| style="text-align: center;  background-color: #EFF5FB" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Profile-icon-9.png|'''[[Pfleger Ana|Ana Pfleger, Mag. ]]'''
+File:Roach_T.jpg|'''[[Roach Thomas|Thomas Roach, PhD ]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[TissueModels]]'''
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
-According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world.
+File:Keller M.PNG|'''[[Keller Markus A| Markus Keller, Dr.]]'''
+File:IOC 2366 cropped.jpg|'''[[Smaling Anna|Anna Smaling, MRes]]'''
-[[OROBOROS_MitoLab:_visiting_scientists| Visiting scientists]]
+</gallery>
+|-
+| style="text-align: left;  background-color: #ffffff" | '''[[MitoKIN]]'''
+| style="text-align: center;  background-color: #EFF5FB" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Stefan E.jpg|'''[[Stefan Eduard|Eduard Stefan, PhD]]'''
+File:Profile-icon-9.png|'''[[Strich Sophie|Sophie Strich]]'''
+File:Torres-QuesadaO.jpg|'''[[Torres-Quesada O|Omar Torres-Quesada, PhD]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[CureMILS]]'''
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Suarez.png|'''[[Suarez-Cubero Marta|Marta Suarez-Cubero]]'''
+</gallery>
+|}
+== OXPHOS analysis ==
+:::: SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
+::::* coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
+::::* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry|cell ergometry]]).
+::::» [[Projects|'''Current projects''']]
+::::» '''[[Partners in the Oroboros Ecosystem]]'''
+::::» [[Oroboros Laboratories: visiting scientists |'''Visiting scientists''']]
+== Keywords ==
+{{Keywords: Oroboros Laboratories}}