Difference between revisions of "Oroboros Laboratory"

Latest revision as of 16:58, 15 February 2024

Oroboros Laboratory

Mitochondria and Cell Research - the Oroboros Ecosystem

Scientists with a gentle touch of entrepreneurship

Oroboros O2k-Laboratory

42 O2k-Chambers (21 O2k)

The Oroboros O2k-Laboratory ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project MitoCom Tyrol in June 2013. It comprises 140 sqm which are divided into the office and research areas.

Twenty-one O2k instruments for HRR (42 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.

Two additional O2ks (4 chambers) are devoted to instrumental development.

According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.

» More details: Oroboros Support

Joint projects

Functional Mitochondrial Diagnostics (VASCage)	Rebecka Hardorp Alejandra Romero-Martinez, Dr. Joshua Wieser-Insole
ALAS	Ana Pfleger, Mag. Thomas Roach, PhD
TissueModels	Markus Keller, Dr. Anna Smaling, MRes
MitoKIN	Eduard Stefan, PhD Sophie Strich Omar Torres-Quesada, PhD
CureMILS	Marta Suarez-Cubero

OXPHOS analysis

SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using

coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping (cell ergometry).

» Current projects

» Partners in the Oroboros Ecosystem

» Visiting scientists

Keywords

Bioblast links: Oroboros Laboratory - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

» Oroboros Laboratory

» Projects

» Oroboros Laboratory: visiting scientists

» O2k-Open Support by Oroboros experts

@@ Line 1: / Line 1: @@
 {{Template:OROBOROS header page name}}
+{{Template:OROBOROS Slogan}}
-== About us ==
+:::: <big>'''Scientists with a gentle touch of entrepreneurship'''</big>
-[[Image:Logo MitoFit.jpg|left|120px|link=http://www.mitofit.org/index.php/MitoFit|MitoFit]]
+[[File:Lab in action.jpg|right|500px|Oroboros Laboratory]]
-The OROBOROS MitoFit Laboratory (MitoFit Lab, 'Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, that is probably the world-wide best equipped lab for high-resolution respirometry. The MitoFit Lab was opened during the course of the K-Regio project [[MitoCom_O2k-Fluorometer| MitoCom Tyrol]], starting in June 2013. It comprises 140 sqm which are divided into the office and research areas.
-=== O2k instruments ===
-'''24 O2k-Chambers (twelve O2k)'''
-* Eight O2k instruments (16 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules are available for scientific research and routine biomedical applications.
-* Two O2ks are used for specific testing.
+<!--[[File:OROBOROS MitoFit-Lab.jpg|left|240px |Oroboros O2k-Laboratory]]-->
-* Two O2ks are devoted to instrumental development.
+__TOC__
+== Oroboros O2k-Laboratory ==
+:::: '''42 O2k-Chambers (21 O2k)'''
-More details: [[O2k-technical_support_and_open_innovation|OROBOROS Support]]
+:::: The '''Oroboros O2k-Laboratory''' ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project [[MitoCom_O2k-Fluorometer| MitoCom Tyrol]] in June 2013. It comprises 140 sqm which are divided into the office and research areas.
+::::* Twenty-one O2k instruments for HRR (42 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.
-=== OXPHOS analysis ===
+::::* Two additional O2ks (4 chambers) are devoted to instrumental development.
-SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
+::::* According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.
-* a phosphorylation control protocol in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
+::::» ''More details:'' [[O2k-technical_support_and_open_innovation|Oroboros Support]]
-* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry|cell ergometry]]).
+=== Joint projects ===
+{| style="color: black;  width: 90%"
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[Functional Mitochondrial Diagnostics]]''' (VASCage)
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Hardorp Rebecka.jpg|'''[[Hardorp Rebecka|Rebecka Hardorp]]'''
+File:Romero Martinez Alejandra.jpeg|'''[[Romero Martinez Alejandra|Alejandra Romero-Martinez, Dr.]]'''
+File:Wieser-Insole J.jpg|'''[[Wieser-Insole Joshua|Joshua Wieser-Insole]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #ffffff" | '''[[ALAS]]'''
+| style="text-align: center;  background-color: #EFF5FB" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Profile-icon-9.png|'''[[Pfleger Ana|Ana Pfleger, Mag. ]]'''
+File:Roach_T.jpg|'''[[Roach Thomas|Thomas Roach, PhD ]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[TissueModels]]'''
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
-=== The MitoFit Centre of Excellence ===
+File:Keller M.PNG|'''[[Keller Markus A| Markus Keller, Dr.]]'''
+File:IOC 2366 cropped.jpg|'''[[Smaling Anna|Anna Smaling, MRes]]'''
-OROBOROS INSTRUMENTS collaborates closely with research labs of the Medical University of Innsbruck, the Ludwig-Franzens University of Innsbruck, and with visiting scientists from numerous internation research institutions.
+</gallery>
+|-
+| style="text-align: left;  background-color: #ffffff" | '''[[MitoKIN]]'''
+| style="text-align: center;  background-color: #EFF5FB" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Stefan E.jpg|'''[[Stefan Eduard|Eduard Stefan, PhD]]'''
+File:Profile-icon-9.png|'''[[Strich Sophie|Sophie Strich]]'''
+File:Torres-QuesadaO.jpg|'''[[Torres-Quesada O|Omar Torres-Quesada, PhD]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[CureMILS]]'''
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
-According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world.
+File:Suarez.png|'''[[Suarez-Cubero Marta|Marta Suarez-Cubero]]'''
-[[OROBOROS_MitoFit_lab:_visiting_scientists| Visiting scientists]]
+</gallery>
+|}
-[[File:ORO Lab 1.jpg|250px]] [[File:ORO Lab 2.jpg|250px]] [[File:ORO Lab 3.jpg|250px]] [[File:ORO Lab 4.jpg|250px]]
+== OXPHOS analysis ==
+:::: SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
-== Current projects and collaborators ==
+::::* coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
-:: '''The [[OROBOROS_Company#The_OROBOROS-Team |OROBOROS-Team]] collaborates with:'''
+::::* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry|cell ergometry]]).
-=== MitoFit project ===
-[[Image:HoppelF.jpg|left|90px]]
+::::» [[Projects|'''Current projects''']]
+::::» '''[[Partners in the Oroboros Ecosystem]]'''
+::::» [[Oroboros Laboratories: visiting scientists |'''Visiting scientists''']]
-:::: '''[[Hoppel F|Florian Hoppel]]''', MSc. - [mailto:[email protected] [email protected]]
+== Keywords ==
-:::: PhD student
+{{Keywords: Oroboros Laboratories}}
-:::: Institute for Sports Science and OROBOROS: [[O2k-MitoFit]]
-[[Image:O2k-MitoFit.jpg|100px|link=http://www.mitofit.org/index.php/O2k-MitoFit|O2k-MitoFit]]
-<br/>
-<br/>
-=== Oncotyrol project ===
-[[Image:SchoepfB.jpg|left|90px]]
-:: '''[[Schoepf B|Bernd Schoepf]]''', Mag., PhD student - [mailto:[email protected] [email protected]]
-:: The [[Oncotyrol| Oncotyrol]] research project has its focus on functional differences of mitochondria in human prostate tumor versus benign tissue. - [http://oroboros.at/index.php?id=oncotyrol Oncotyrol]
-:: Project leader: A.Univ. Prof. Mag. Dr. Helmut Klocker, Dept. Urology, Medical University Innsbruck, Peter-Anich-Str. 35, 6020 Innsbruck, Austria
-<br/>
-<br/>
-<br/>
-::::'''[[Weber B| Benno Weber]]''', [mailto:[email protected] [email protected]]
-:::: The [[Oncotyrol| Oncotyrol]] research project has its focus on functional differences of mitochondria in human prostate tumor versus benign tissue. - [http://oroboros.at/index.php?id=oncotyrol Oncotyrol]
-<br/>
-::::'''[[Laschober G| Gerhard Laschober]]''', [mailto:[email protected] [email protected]]
-:::: The [[Oncotyrol| Oncotyrol]] research project has its focus on functional differences of mitochondria in human prostate tumor versus benign tissue. - [http://oroboros.at/index.php?id=oncotyrol Oncotyrol]
-<br/>
-::::'''[[Weber A| Anja Weber]]''', [mailto:[email protected]  [email protected]]
-:::: The [[Oncotyrol| Oncotyrol]] research project has its focus on functional differences of mitochondria in human prostate tumor versus benign tissue. - [http://oroboros.at/index.php?id=oncotyrol Oncotyrol]
-<br/>
-=== Pharmacology project ===
-[[Image:Johannes.jpg|left|90px|Johannes Burtscher]]
-:: '''[[Burtscher J|Johannes Burtscher]]''', Mag., PhD student
-:: FWF projects W1206-B05 and I-977-B24.
-:: Project leader: A.Univ. Prof. Dr. Christian Schwarzer, Dept. Pharmacology, Medical University Innsbruck, Peter-Mayr-Str. 1a, 6020 Innsbruck, Austria
-<br/>
-<br/>
-<br/>
-::::'''[[Volani C| Chiara Volani]]''', [mailto:[email protected] [email protected]]