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Oncotyrol - Revision history
2024-03-29T06:47:47Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Oncotyrol&diff=171189&oldid=prev
Beno Marija at 11:21, 23 January 2019
2019-01-23T11:21:48Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:21, 23 January 2019</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">OROBOROS </del>Instruments GmbH, Innsbruck</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Oroboros </ins>Instruments GmbH, Innsbruck</div></td></tr>
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Beno Marija
https://wiki.oroboros.at/index.php?title=Oncotyrol&diff=87208&oldid=prev
Strasser Nina at 07:30, 16 April 2015
2015-04-16T07:30:07Z
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Logo oncotyrol.jpg|250px|right|Oncotyrol]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Logo oncotyrol.jpg|250px|right|Oncotyrol]]</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Project Title ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Project Title ==</div></td></tr>
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Strasser Nina
https://wiki.oroboros.at/index.php?title=Oncotyrol&diff=87205&oldid=prev
Strasser Nina: /* Objectives */
2015-04-16T07:21:53Z
<p><span dir="auto"><span class="autocomment">Objectives</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:21, 16 April 2015</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Our recent study on mtDNA mutations in prostate cancer revealed 41 somatic mutations in 22 out of 30 patients <del style="font-weight: bold; text-decoration: none;">[1]</del>. The presence of somatic mutations in transfer RNAs (tRNAs) was found to be associated with elevated PSA levels. The level and degree of heteroplasmy increased with increasing tumor grade. Mutations in mitochondrial tRNAs, ribosomal RNAs or protein coding genes might impair mitochondrial function and promote a shift towards increased anaerobic glycolysis.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Our recent study on mtDNA mutations in prostate cancer revealed 41 somatic mutations in 22 out of 30 patients. The presence of somatic mutations in transfer RNAs (tRNAs) was found to be associated with elevated PSA levels. The level and degree of heteroplasmy increased with increasing tumor grade. Mutations in mitochondrial tRNAs, ribosomal RNAs or protein coding genes might impair mitochondrial function and promote a shift towards increased anaerobic glycolysis.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2"></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Expected Resuts ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Expected Resuts ==</div></td></tr>
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Strasser Nina
https://wiki.oroboros.at/index.php?title=Oncotyrol&diff=87204&oldid=prev
Strasser Nina at 07:03, 16 April 2015
2015-04-16T07:03:51Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:03, 16 April 2015</td>
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Logo oncotyrol.jpg|250px|right|Oncotyrol]]</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Project Title ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Project Title ==</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Funding ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Funding ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> </del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Forschung wirkt logo.png|200px|right|Forschung wirkt]] </ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">FFG (State) funding: € 222.222,22 Basis of assessment of the fundable costs: € 444.444,44</ins></div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">FFG (State) funding: € 222.222,22 Basis of assessment of the fundable costs: € 444.444,44</del></div></td><td colspan="2"></td></tr>
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Strasser Nina
https://wiki.oroboros.at/index.php?title=Oncotyrol&diff=87202&oldid=prev
Strasser Nina: Created page with "== Project Title == Mitochondrial markers for prostate cancer prognosis and therapy == Objectives == Mitochondria are crucial organelles for energy production, apoptosis and..."
2015-04-16T06:59:42Z
<p>Created page with "== Project Title == Mitochondrial markers for prostate cancer prognosis and therapy == Objectives == Mitochondria are crucial organelles for energy production, apoptosis and..."</p>
<p><b>New page</b></p><div>== Project Title ==<br />
<br />
Mitochondrial markers for prostate cancer prognosis and therapy<br />
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<br />
== Objectives ==<br />
<br />
<br />
Mitochondria are crucial organelles for energy production, apoptosis and intracellular production of reactive oxygen species (ROS). A shift in cellular energy production from oxidative phosphorylation in mitochondria to anaerobic glycolysis is a fundamental property of cancer cells. Due to the essential role of enzymes encoded by the mitochondrial DNA (mtDNA) in energy metabolism, alterations of the mtDNA have been suspected to be able to cause a metabolic shift in tumors. Because mitochondria play important roles in both ROS production and apoptosis, the conclusion that they could influence the occurrence and especially the progression of cancer is obvious. There is accumulating evidence of a role of mitochondria in different tumor types, among them prostate cancer.<br />
<br />
<br />
The exploitation of alterations of mitochondrial function and genome during prostate cancer development and progression is expected to uncover surrogate markers that will result in new diagnostic procedures; in addition, the identification of mitochondrial targets could lead to the development of new drugs for prevention and treatment.<br />
<br />
<br />
Our recent study on mtDNA mutations in prostate cancer revealed 41 somatic mutations in 22 out of 30 patients [1]. The presence of somatic mutations in transfer RNAs (tRNAs) was found to be associated with elevated PSA levels. The level and degree of heteroplasmy increased with increasing tumor grade. Mutations in mitochondrial tRNAs, ribosomal RNAs or protein coding genes might impair mitochondrial function and promote a shift towards increased anaerobic glycolysis.<br />
<br />
<br />
== Expected Resuts ==<br />
<br />
* Information on the role of mitochondria in tumor development, progression, therapy resistance.<br />
<br />
* Mitochondrial markers for prostate cancer to be used in diagnosis, prognosis and risk assessment and selection of therapy. Surrogate markers for mitochondrial function and energy metabolism.<br />
<br />
* Putative mitochondrial therapy targets.<br />
<br />
<br />
<br />
== Partners ==<br />
<br />
Oncotyrol - Center for Personalized Cancer Medicine GmbH<br />
<br />
Division of Genetic Epidemiology, Innsbruck Medical University<br />
<br />
Department of Urology, Innsbruck Medical University<br />
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OROBOROS Instruments GmbH, Innsbruck<br />
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Theracode GmbH, Mainz<br />
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== Project Duration ==<br />
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2012-07-01 to 2015-06-30<br />
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== Funding ==<br />
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FFG (State) funding: € 222.222,22 Basis of assessment of the fundable costs: € 444.444,44<br />
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== Contact ==<br />
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[[Schoepf B| Bernd Schöpf, Mag.]]<br />
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[[Laner V| Verena Laner , Mag. Biol.]]</div>
Strasser Nina