Difference between revisions of "Oliveira 2011 Insect Biochem Mol Biol"
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Revision as of 12:05, 17 November 2011
| Oliveira JH, Gonçalves RL, Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury C (2011) Energy metabolism affects susceptibility of Anophelesgambiae mosquitoes to Plasmodium infection. Insect Biochem. Mol. Biol. 41: 349-355. |
Oliveira JH, Goncalves RL, Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury M (2011) Insect Biochem Mol Biol
Abstract: Previous studies showed that Anopheles gambiae L3-5 females, which are refractory (R) to Plasmodium infection, express higher levels of genes involved in redox-metabolism and mitochondrial respiration than susceptible (S) G3 females. Our studies revealed that R females have reduced longevity, faster utilization of lipid reserves, impaired mitochondrial State 3 respiration, increased rate of mitochondrial electron leak and higher expression levels of several glycolytic enzyme genes. Furthermore, when State 3 respiration was reduced in S females by silencing expression of the adenine nucleotide translocator (ANT), hydrogen peroxide generation was higher and the mRNA levels of lactate dehydrogenase increased in the midgut, while the prevalence and intensity of Plasmodiumberghei infection were significantly reduced. We conclude that there are broad metabolic differences between R and S An. gambiae mosquitoes that influence their susceptibility to Plasmodium infection. • Keywords: Mosquito; Anopheles gambiae; Metabolism; Mitochondria; Plasmodium infection; Refractoriness; Electron leak; Reactive oxygen species
• O2k-Network Lab: BR_Rio De Janeiro_Oliveira MF
Labels:
Stress:RONS; Oxidative Stress"RONS; Oxidative Stress" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property. Organism: Other Non-Mammal"Other Non-Mammal" is not in the list (Human, Pig, Mouse, Rat, Guinea pig, Bovines, Horse, Dog, Rabbit, Cat, ...) of allowed values for the "Mammal and model" property.
HRR: Oxygraph-2k
