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Noncoupled respiration

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Noncoupled respiration

Description

E.jpg Noncoupled respiration is distinguished from general (pharmacological or mechanical) uncoupled respiration, to give a label to an effort to reach the state of maximum uncoupler-activated respiration without inhibiting respiration. Noncoupled respiration, therefore, yields an estimate of ET capacity. Experimentally uncoupled respiration may fail to yield an estimate of ET capacity, due to inhibition of respiration above optimum uncoupler concentrations or insufficient stimulation by sub-optimal uncoupler concentrations. Optimum uncoupler concentrations for evaluation of (noncoupled) ET capacity require inhibitor titrations (Steinlechner-Maran 1996 Am J Physiol Cell Physiol; Huetter 2004 Biochem J; Gnaiger 2008 POS).

Noncoupled respiration is maximum electron flow in an open-transmembrane proton circuit mode of operation (see ET capacity).

Abbreviation: E

Reference: Gnaiger 2014 MitoPathways, MitoPedia: Respiratory states


MitoPedia concepts: Respiratory state, Recommended 


MitoPedia methods: Respirometry 


MitoPedia topics: EAGLE 

Contributed by Gnaiger E 2010-08-15, edited 2015-01-19.

Is respiration uncoupled - noncoupled - dyscoupled?

» More details: Uncoupler

Biochemical coupling efficiency: from 0 to <1

» More details: OXPHOS coupling efficiency and ET-pathway coupling efficiency


Related MitoPedia pages

  • Electron transfer-pathway, ET-pathway
» Electron transfer-pathway
» Q-junction
  • Pathway control states
» Pathway control state
  • Coupling control state E
E.jpg ET capacity
» Noncoupled respiration
» Is respiration uncoupled - noncoupled - dyscoupled?