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Noland Robert C

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Name Noland Robert C, Assistant Professor, PhD
Institution Pennington Biomedical Research Center
Address , LA 70808
City Baton Rouge
State/Province
Country USA
Email [email protected]
Weblink
O2k-Network Lab US LA Baton Rouge Noland RC


Labels: Field of research: Basic 



Publications

 PublishedReference
Axelrod 2021 EMBO Mol Med2021Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.
King 2021 J Biol Chem2021King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, Lรณpez-Domรจnech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.

Abstracts

 PublishedReference
Axelrod 2019 Abstract IOC1412019Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02.
  • My research primarily focuses on exploring mechanisms linking dysregulation of lipid metabolism to pre-diabetes and diabetes. Chief among these are the potential role of aberrant mitochondrial and peroxisomal function contributing to the development of lipid-induced insulin resistance. Currently my laboratory assesses mitochondrial function by protein/gene expression, enzymatic activity, direct measurement of substrate metabolism using radiolabeled tracer technology, and metabolomic/lipidomic profiling. The OROBOROS-O2k ISE Multisensor System will greatly increase our ability to comprehensively test mitochondrial function which is anticipated to not only strengthen results obtained from our studies, but also provide novel insight that will guide future experimental exploration.

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