Difference between revisions of "Nicotinamide adenine dinucleotide"

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Nicotinamide adenine dinucleotide

Description

Nicotinamide adenine dinucleotide, NAD⁺ and NADH, is an oxidation-reduction coenzyme (redox cofactor; compare FADH2). Type N substrates of mt-matrix dehydrogenases generate NADH, the substrate of Complex I (CI). Thus the mt-NADH pool integrates the activity of the TCA cycle and various matrix dehydrogenases upstream of CI, and thus forms a junction or funnel of electron transfer to CI, the N-junction (compare F-junction, Q-junction). NAD⁺ and NADH are not permeable through the inner mt-membrane. Cytosolic NADH is effectively made available for mitochondrial respiration through the malate-aspartate shuttle or glycerophosphate dehydrogenase Complex.

Abbreviation: NADH

MitoPedia topics: Substrate and metabolite

Labels:

Enzyme: Complex I

Application in HRR

Nicotinadeninedinucleotide, NADH (β-Nicotinamide adenine dinucleotide, reduced potassium salt, C₂₁H₂₇N₇O₁₄P₂K₂); Sigma A 4505, 100 mg, store at -20 °C (old Sigma recommendation: 4-8 °C); FW = 742.61, for important considerations concerning storage of NADH (powder and solutions) and preparation of solutions see the product information from Sigma: [1]. The same precautions are recommended by Sigma for the sodium salt.

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 {{MitoPedia
 |abbr=NADH
-|description='''Nicotinamide adenine dinucleotide''', NAD<sup>+</sup> and NADH, is an oxidation-reduction coenzyme (redox cofactor; compare [[FADH2]]). [[Substrate types |Type N substrates]] of mt-matrix dehydrogenases generate NADH, the substrate of [[Complex I]] (CI). Thus the mt-NADH pool integrates the activity of the [[TCA cycle]] and various matrix dehydrogenases upstream of CI, and thus forms a junction or funnel of electron transfer to CI, the [[N-junction]] (compare [[F-junction]], [[Q-junction]]). NAD<sup>+</sup> and NADH are not permeable through the inner mt-membrane. Cytosolic NADH is effectively made available for mitochondrial respiration through the [[malate-aspartate shuttle]] or [[Glycerophosphate_dehydrogenase_complex|glycerophosphate dehydrogenase Complex]].
+|description='''Nicotinamide adenine dinucleotide''', NAD<sup>+</sup> and NADH, is an oxidation-reduction coenzyme (redox cofactor; compare [[FADH2]]). [[ETS substrate types |Type N substrates]] of mt-matrix dehydrogenases generate NADH, the substrate of [[Complex I]] (CI). Thus the mt-NADH pool integrates the activity of the [[TCA cycle]] and various matrix dehydrogenases upstream of CI, and thus forms a junction or funnel of electron transfer to CI, the [[N-junction]] (compare [[F-junction]], [[Q-junction]]). NAD<sup>+</sup> and NADH are not permeable through the inner mt-membrane. Cytosolic NADH is effectively made available for mitochondrial respiration through the [[malate-aspartate shuttle]] or [[Glycerophosphate_dehydrogenase_complex|glycerophosphate dehydrogenase Complex]].
 |type=Substrate ETS
 }}