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Difference between revisions of "Net R/E control ratio"

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{{MitoPedia
{{MitoPedia
|abbr=''≈R/E''
|abbr=(''R-L'')/''E''
|description=The '''ROUTINE phosphorylation control ratio''' (''≈R'' control ratio), ''≈R/E'' = (''R-L'')/''E'', expresses phosphorylation-related respiration (corrected for [[LEAK respiration]]) as a fraction of [[ETS capacity]]. ''≈R/E'' remains constant, if [[dyscoupling]] is fully compensated by an increase of ROUTINE respiration and [[respiratory ROUTINE phosphorylation]] (''≈R'' = ''R-L'') is maintained constant.
|description=[[Image:NetR over E.jpg|60 px|net R/E control ratio]] The '''net ''R/E'' control ratio''', (''R-L'')/''E'', expresses phosphorylation-related respiration (corrected for [[LEAK respiration]]) as a fraction of [[ET capacity]]. The net ''R/E'' control ratio remains constant, if [[dyscoupling]] is fully compensated by an increase of ROUTINE respiration and [[R-L net ROUTINE capacity]], ''R-L'', is maintained constant.
|info=[[Pesta 2012 Methods Mol Biol]]
|info=[[Gnaiger 2020 BEC MitoPathways]], [[Huetter 2004 Biochem J]]
|type=Respiration
}}
}}
{{MitoPedia methods
 
|mitopedia method=Respirometry
== Keywords ==
|type=Respiration
{{Template:Keywords: Coupling control}}
 
{{MitoPedia concepts
|mitopedia concept=Respiratory control ratio, Ergodynamics
}}
}}
{{MitoPedia topics
 
|mitopedia topic=Respiratory control ratio
[[Category:Coupling control]]
|type=Respiration
}}
== Compare ==
* [[ROUTINE phosphorylation control factor]]
* ''More details:'' »[[Biochemical coupling efficiency]]

Latest revision as of 00:13, 31 December 2020


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Net R/E control ratio

Description

net R/E control ratio The net R/E control ratio, (R-L)/E, expresses phosphorylation-related respiration (corrected for LEAK respiration) as a fraction of ET capacity. The net R/E control ratio remains constant, if dyscoupling is fully compensated by an increase of ROUTINE respiration and R-L net ROUTINE capacity, R-L, is maintained constant.

Abbreviation: (R-L)/E

Reference: Gnaiger 2020 BEC MitoPathways, Huetter 2004 Biochem J


Keywords


Questions.jpg


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Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

1. Mitochondrial and cellular respiratory rates in coupling-control states

OXPHOS-coupled energy cycles. Source: The Blue Book
» Baseline state
Respiratory rate Defining relations Icon
OXPHOS capacity P = -Rox P.jpg mt-preparations
ROUTINE respiration R = -Rox R.jpg living cells
ET capacity E = -Rox E.jpg » Level flow
» Noncoupled respiration - Uncoupler
LEAK respiration L = -Rox L.jpg » Static head
» LEAK state with ATP
» LEAK state with oligomycin
» LEAK state without adenylates
Residual oxygen consumption Rox L = -Rox ROX.jpg
  • Chance and Williams nomenclature: respiratory states
» State 1 —» State 2 —» State 3 —» State 4 —» State 5

2. Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio
» Coupling-control ratio
» Coupling-control protocol
FCR Definition Icon
L/P coupling-control ratio L/P L/P coupling-control ratio » Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio L/R L/R coupling-control ratio
L/E coupling-control ratio L/E L/E coupling-control ratio » Uncoupling-control ratio, UCR = E/L (ambiguous)
P/E control ratio P/E P/E control ratio
R/E control ratio R/E R/E control ratio » Uncoupling-control ratio, UCR = E/L
net P/E control ratio (P-L)/E net P/E control ratio
net R/E control ratio (R-L)/E net R/E control ratio

3. Net, excess, and reserve capacities of respiration

Respiratory net rate Definition Icon
P-L net OXPHOS capacity P-L P-L net OXPHOS capacity
R-L net ROUTINE capacity R-L R-L net ROUTINE capacity
E-L net ET capacity E-L E-L net ET capacity
E-P excess capacity E-P E-P excess capacity
E-R reserve capacity E-R E-R reserve capacity

4. Flux control efficiencies related to coupling-control ratios

» Flux control efficiency jZ-Y
» Background state
» Reference state
» Metabolic control variable
Coupling-control efficiency Definition Icon Canonical term
P-L control efficiency jP-L = (P-L)/P = 1-L/P P-L control efficiency P-L OXPHOS-flux control efficiency
R-L control efficiency jR-L = (R-L)/R = 1-L/R R-L control efficiency R-L ROUTINE-flux control efficiency
E-L coupling efficiency jE-L = (E-L)/E = 1-L/E E-L coupling efficiency E-L ET-coupling efficiency » Biochemical coupling efficiency
E-P control efficiency jE-P = (E-P)/E = 1-P/E E-P control efficiency E-P ET-excess flux control efficiency
E-R control efficiency jE-R = (E-R)/E = 1-R/E E-R control efficiency E-R ET-reserve flux control efficiency

5. General

» Basal respiration
» Cell ergometry
» Dyscoupled respiration
» Dyscoupling
» Electron leak
» Electron-transfer-pathway state
» Hyphenation
» Oxidative phosphorylation
» Oxygen flow
» Oxygen flux
» Permeabilized cells
» Phosphorylation system
» Proton leak
» Proton slip
» Respiratory state
» Uncoupling



MitoPedia concepts: Respiratory control ratio, Ergodynamics