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Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis - Revision history
2024-03-28T14:55:08Z
Revision history for this page on the wiki
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Komlodi Timea at 08:00, 4 December 2020
2020-12-04T08:00:39Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/31953215 PMID: 31953215 Open Access]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/31953215 PMID: 31953215 Open Access]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|authors=Nascimento-Dos-Santos <del style="font-weight: bold; text-decoration: none;">G</del>, de-Souza-Ferreira <del style="font-weight: bold; text-decoration: none;">E</del>, Lani <del style="font-weight: bold; text-decoration: none;">R</del>, de Faria <del style="font-weight: bold; text-decoration: none;">CC</del>, Araujo <del style="font-weight: bold; text-decoration: none;">VG</del>, Teixeira-Pinheiro <del style="font-weight: bold; text-decoration: none;">LC</del>, de Souza Vasconcelos <del style="font-weight: bold; text-decoration: none;">T</del>, <del style="font-weight: bold; text-decoration: none;">Leandro TG</del>, Santiago <del style="font-weight: bold; text-decoration: none;">MF</del>, Linden <del style="font-weight: bold; text-decoration: none;">R</del>, Galina <del style="font-weight: bold; text-decoration: none;">A</del>, Petrs-Silva <del style="font-weight: bold; text-decoration: none;">H</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|authors=Nascimento-Dos-Santos <ins style="font-weight: bold; text-decoration: none;">Gabriel</ins>, de-Souza-Ferreira <ins style="font-weight: bold; text-decoration: none;">Eduardo</ins>, Lani <ins style="font-weight: bold; text-decoration: none;">Rafael</ins>, de Faria <ins style="font-weight: bold; text-decoration: none;">Caroline Coelho</ins>, Araujo <ins style="font-weight: bold; text-decoration: none;">Victor Guedes</ins>, Teixeira-Pinheiro <ins style="font-weight: bold; text-decoration: none;">Leandro Coelho</ins>, de Souza Vasconcelos <ins style="font-weight: bold; text-decoration: none;">Taliane</ins>, <ins style="font-weight: bold; text-decoration: none;">Thais Goncalo</ins>, Santiago <ins style="font-weight: bold; text-decoration: none;">Marcelo Felippe</ins>, Linden <ins style="font-weight: bold; text-decoration: none;">Rafael</ins>, Galina <ins style="font-weight: bold; text-decoration: none;">Antonio</ins>, Petrs-Silva <ins style="font-weight: bold; text-decoration: none;">Hilda</ins></div></td></tr>
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Komlodi Timea
https://wiki.oroboros.at/index.php?title=Nascimento-Dos-Santos_2020_Biochim_Biophys_Acta_Mol_Basis_Dis&diff=200682&oldid=prev
Plangger Mario at 13:37, 7 May 2020
2020-05-07T13:37:00Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:37, 7 May 2020</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis <del style="font-weight: bold; text-decoration: none;">[Epub ahead of print]</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis <ins style="font-weight: bold; text-decoration: none;">1866:165686</ins>.</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Nascimento-Dos-Santos_2020_Biochim_Biophys_Acta_Mol_Basis_Dis&diff=191475&oldid=prev
Plangger Mario at 14:40, 29 January 2020
2020-01-29T14:40:32Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:40, 29 January 2020</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|diseases=Neurodegenerative</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|diseases=Neurodegenerative</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Nascimento-Dos-Santos_2020_Biochim_Biophys_Acta_Mol_Basis_Dis&diff=191469&oldid=prev
Plangger Mario at 13:55, 29 January 2020
2020-01-29T13:55:54Z
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Nascimento-Dos-Santos_2020_Biochim_Biophys_Acta_Mol_Basis_Dis&diff=191468&oldid=prev
Plangger Mario: Created page with "{{Publication |title=Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linde..."
2020-01-29T13:55:08Z
<p>Created page with "{{Publication |title=Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linde..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis [Epub ahead of print].<br />
|info=[https://www.ncbi.nlm.nih.gov/pubmed/31953215 PMID: 31953215 Open Access]<br />
|authors=Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H<br />
|year=2020<br />
|journal=Biochim Biophys Acta Mol Basis Dis<br />
|abstract=Mitochondrial dysfunctions are linked to a series of neurodegenerative human conditions, including Parkinson's disease, schizophrenia, optic neuropathies, and glaucoma. Recently, a series of studies have pointed mitotherapy - exogenous mitochondria transplant - as a promising way to attenuate the progression of neurologic disorders; however, the neuroprotective and pro-regenerative potentials of isolated mitochondria ''in vivo'' have not yet been elucidated. In this present work, we tested the effects of transplants of active (as well-coupled organelles were named), liver-isolated mitochondria on the survival of retinal ganglion cells and axonal outgrowth after optic nerve crush. Our data show that intravitreally transplanted, full active mitochondria incorporate into the retina, improve its oxidative metabolism and electrophysiological activity at 1 day after transplantation. Moreover, mitotherapy increases cell survival in the ganglion cell layer at 14 days, and leads to a higher number of axons extending beyond the injury site at 28 days; effects that are dependent on the organelles' structural integrity. Together, our findings support mitotherapy as a promising approach for future therapeutic interventions upon central nervous system damage.<br />
<br />
<small>Copyright © 2020. Published by Elsevier B.V.</small><br />
|keywords=Active mitochondria, CNS neuroprotection, Glaucoma, Mitochondria transplantation, Mitotherapy, Optic nerve crush<br />
|editor=[[Plangger M]],<br />
}}<br />
{{Labeling<br />
|area=Respiration, mt-Medicine<br />
|diseases=Neurodegenerative<br />
|tissues=Liver<br />
|preparations=Isolated mitochondria<br />
|instruments=Oxygraph-2k<br />
|additional=Labels, 2020-01,<br />
}}</div>
Plangger Mario